Aims—The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. Methods and results—We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of personsaged 65–95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α) were measured. Complete information on potential confounders was collected using standard methods. WBC (P = 0.0001), neutrophils (P < 0.0001), C-reactive protein (P < 0.0001), IL-1ra (P < 0.0001), IL-6 (P = 0.0004), sIL-6r (P = 0.002), IL-18 (P < 0.0001), TNF-α (P = 0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P = 0.004) and IL-6 (P = <0. 0001) were significantly higher across UA quintiles. After adjustment for age, sex, behaviour- and disease-related confounders, results were virtually unchanged. In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C- reactive protein, IL-6, IL-1ra, IL-18, and TNF-α, whereas non-significant trends were observed for WBC (P = 0.1) and sIL-6r (P = 0.2). Conclusion—A positive and significant association between UA and several inflammatory markers was found in a large population-based sample of older persons and in a sub-sample of participants with normal UA. Accordingly, the prevalence of abnormally high levels of C-reactive protein and IL-6 increased significantly across UA quintiles

Uric acid and inflammatory markers / Ruggiero, C; Cherubini, A; Ble, A; Bos, Ajg; Maggio, Marcello Giuseppe; Lauretani, F; Bandinelli, S; Senin, U; Ferrucci, L.. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 27:(2006), pp. 1174-1181. [10.1093/eurheartj/ehi879]

Uric acid and inflammatory markers.

MAGGIO, Marcello Giuseppe;LAURETANI F;
2006-01-01

Abstract

Aims—The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. Methods and results—We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of personsaged 65–95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α) were measured. Complete information on potential confounders was collected using standard methods. WBC (P = 0.0001), neutrophils (P < 0.0001), C-reactive protein (P < 0.0001), IL-1ra (P < 0.0001), IL-6 (P = 0.0004), sIL-6r (P = 0.002), IL-18 (P < 0.0001), TNF-α (P = 0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P = 0.004) and IL-6 (P = <0. 0001) were significantly higher across UA quintiles. After adjustment for age, sex, behaviour- and disease-related confounders, results were virtually unchanged. In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C- reactive protein, IL-6, IL-1ra, IL-18, and TNF-α, whereas non-significant trends were observed for WBC (P = 0.1) and sIL-6r (P = 0.2). Conclusion—A positive and significant association between UA and several inflammatory markers was found in a large population-based sample of older persons and in a sub-sample of participants with normal UA. Accordingly, the prevalence of abnormally high levels of C-reactive protein and IL-6 increased significantly across UA quintiles
2006
Uric acid and inflammatory markers / Ruggiero, C; Cherubini, A; Ble, A; Bos, Ajg; Maggio, Marcello Giuseppe; Lauretani, F; Bandinelli, S; Senin, U; Ferrucci, L.. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 27:(2006), pp. 1174-1181. [10.1093/eurheartj/ehi879]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1631797
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