Adult Turner syndrome (TS) patients frequently present hypertension. To clarify the pathogenesis of this hypertension we examined the blood pressure (BP) behaviour and the renin-angiotensin-aldosterone system in 31 TS patients (2-22 years of age). BP levels were occasionally elevated in 47% of the subjects and constantly elevated in 23%. Most of the patients were on estrogen replacement therapy, but 26% of them presented with elevated levels since childhood. Supine and upright plasma renin activity (PRA) values were higher in TS compared to controls and more elevated in hypertensive TS than in the normotensive ones. At Captopril challenge TS showed different PRA responses regardless of the karyotype and clinical features. Patients on estrogen therapy, however, exhibited higher increments of PRA after Captopril. Conclusions: TS patients show high frequency of hypertension in pediatric age. Estrogen therapy is an outbreaking and worsening factor. An estrogen independent role of the renin-angiotensin-aldosterone system in the pathogenesis of TS hypertension is still uncertain.
Blood pressure behaviour and control in Turner syndrome / VIRDIS R; CANTU MC; GHIZZONI L; AMMENTI A; NORI G; VOLTA C; CRAVIDI C; VANELLI M.; BALESTRAZZI P; BERNASCONI S ET AL. - In: CLINICAL AND EXPERIMENTAL HYPERTENSION. PART A, THEORY AND PRACTICE. - ISSN 0730-0077. - 8 (4-5)(1986), pp. 787-791.
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