Adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. Knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance. PATIENTS AND METHODS: 68 patients (29 boys and 39 girls), aged from 5 yr 2 mo to 19 yr 10 mo, and treated for insulin-dependent diabetes from 1 mo to 14 yr 6 mo, were included in the study. Fasting blood concentrations of gastrin (G), pepsinogen (PG1), anti-gastric parietal cell antibodies (PCA) were measured. Fiberoptic endoscopy and biopsy of the gastroduodenal mucosa were performed in PCA+ patients and biopsy samples were examined for Helicobacter pylori (HP). RESULTS: 12 patients were PCA+; 3 of them had blood gastrin levels above 104 pg/ml and 4 had blood pepsinogen levels 24 ng/ml. Histologically, 3 patients had chronic diffuse gastritis (2 were HP+); 2 had chronic gastritis restricted to the antro-pyloric area (both were HP+); 3 had follicular lymphoid hyperplasia (without HP) and 4 had normal mucosa (without HP). CONCLUSION: The presence of PCA can predict the risk of chronic gastritis, possibly auto-immune in origin, in children with insulin-dependent diabetes.

Anti-gastric antibodies and gastritis in insulin-dependent diabetes in children / DE ANGELIS, Gian Luigi; Apollionio, G; Boselli, E; DE FANTI, A; DE LUCA, F; Fulgido, S; Romanini, E; Vanelli, Maurizio. - In: ARCHIVES FRANCAISES DE PEDIATRIE. - ISSN 0003-9764. - 50 (6):(1993), pp. 475-478.

Anti-gastric antibodies and gastritis in insulin-dependent diabetes in children.

DE ANGELIS, Gian Luigi;VANELLI, Maurizio
1993-01-01

Abstract

Adult patients with insulin-dependent diabetes mellitus frequently also show gastric disturbances. Knowledge of the prevalence of such abnormalities in children with insulin-dependent diabetes and the predictive value of anti-gastric parietal cell antibodies in blood may be of practical importance. PATIENTS AND METHODS: 68 patients (29 boys and 39 girls), aged from 5 yr 2 mo to 19 yr 10 mo, and treated for insulin-dependent diabetes from 1 mo to 14 yr 6 mo, were included in the study. Fasting blood concentrations of gastrin (G), pepsinogen (PG1), anti-gastric parietal cell antibodies (PCA) were measured. Fiberoptic endoscopy and biopsy of the gastroduodenal mucosa were performed in PCA+ patients and biopsy samples were examined for Helicobacter pylori (HP). RESULTS: 12 patients were PCA+; 3 of them had blood gastrin levels above 104 pg/ml and 4 had blood pepsinogen levels 24 ng/ml. Histologically, 3 patients had chronic diffuse gastritis (2 were HP+); 2 had chronic gastritis restricted to the antro-pyloric area (both were HP+); 3 had follicular lymphoid hyperplasia (without HP) and 4 had normal mucosa (without HP). CONCLUSION: The presence of PCA can predict the risk of chronic gastritis, possibly auto-immune in origin, in children with insulin-dependent diabetes.
1993
Anti-gastric antibodies and gastritis in insulin-dependent diabetes in children / DE ANGELIS, Gian Luigi; Apollionio, G; Boselli, E; DE FANTI, A; DE LUCA, F; Fulgido, S; Romanini, E; Vanelli, Maurizio. - In: ARCHIVES FRANCAISES DE PEDIATRIE. - ISSN 0003-9764. - 50 (6):(1993), pp. 475-478.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1508806
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