Human herpesvirus (HHV)-7 is a ubiquitous virus that infects >90% of adults. We show that HHV-7 impairs beta2-microglobulin and human leukocyte antigen (HLA) class I and II expression in lymphoid cells in vitro. Accordingly, infected cells were more sensitive to peripheral blood natural cytotoxic activity than were uninfected cells. Analysis of beta2-microglobulin and HLA expression in biopsy specimens from human submandibular glands confirmed the ability of HHV-7 to modulate the expression of these antigens in vivo. We demonstrate that the down-modulation of HLA by HHV-7 is linked to viral replication and is not merely a consequence of the interaction of virions with the cell surface. Infected cells can therefore efficiently escape host immune pressure, which might explain the persistence of HHV-7-positive cells in several kinds of tumors and chronic infectious diseases.
Down-regulation of human leukocyte antigen class I and II and beta2-microglobulin expression in human herpesvirus-7-infected cells / Mirandola, Prisco; Sponzilli, Ivonne; Solenghi, E.; Micheloni, Cristina; Rinaldi, Laura; Gobbi, Giuliana; Vitale, Marco. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 193(7):(2006), pp. 917-926. [10.1086/500561]
Down-regulation of human leukocyte antigen class I and II and beta2-microglobulin expression in human herpesvirus-7-infected cells
MIRANDOLA, Prisco;SPONZILLI, Ivonne;MICHELONI, Cristina;RINALDI, Laura;GOBBI, Giuliana;VITALE, Marco
2006-01-01
Abstract
Human herpesvirus (HHV)-7 is a ubiquitous virus that infects >90% of adults. We show that HHV-7 impairs beta2-microglobulin and human leukocyte antigen (HLA) class I and II expression in lymphoid cells in vitro. Accordingly, infected cells were more sensitive to peripheral blood natural cytotoxic activity than were uninfected cells. Analysis of beta2-microglobulin and HLA expression in biopsy specimens from human submandibular glands confirmed the ability of HHV-7 to modulate the expression of these antigens in vivo. We demonstrate that the down-modulation of HLA by HHV-7 is linked to viral replication and is not merely a consequence of the interaction of virions with the cell surface. Infected cells can therefore efficiently escape host immune pressure, which might explain the persistence of HHV-7-positive cells in several kinds of tumors and chronic infectious diseases.File | Dimensione | Formato | |
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