Paraoxonase (PON1) is a liver and plasma enzyme that hydrolyzes the active metabolites of several organophosphorus insecticides, PON1 displays several polymorphisms that influence both its level of expression and its catalytic activity, thereby determining the rates at which a given individual will detoxify a specific insecticide. Studies in genetically modified mice have elucidated the role played by PON1 in modulating the toxicity of organophosphates. Low PON1 activity during early development may be involved in the enhanced sensitivity of the young toward organophosphate toxicity. Studies in humans should assess PON1 status of individuals, which takes into account both genetic polymorphisms and plasma activity.

Gene-environemnt interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity / Costa, Lucio Guido; Cole, Tb; Furlong, Ce. - In: LABORATORY MEDICINE. - ISSN 0007-5027. - 37:(2006), pp. 109-113. [10.1309/020XQ8HQJJTTJDK4]

Gene-environemnt interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity

COSTA, Lucio Guido;
2006-01-01

Abstract

Paraoxonase (PON1) is a liver and plasma enzyme that hydrolyzes the active metabolites of several organophosphorus insecticides, PON1 displays several polymorphisms that influence both its level of expression and its catalytic activity, thereby determining the rates at which a given individual will detoxify a specific insecticide. Studies in genetically modified mice have elucidated the role played by PON1 in modulating the toxicity of organophosphates. Low PON1 activity during early development may be involved in the enhanced sensitivity of the young toward organophosphate toxicity. Studies in humans should assess PON1 status of individuals, which takes into account both genetic polymorphisms and plasma activity.
2006
Gene-environemnt interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity / Costa, Lucio Guido; Cole, Tb; Furlong, Ce. - In: LABORATORY MEDICINE. - ISSN 0007-5027. - 37:(2006), pp. 109-113. [10.1309/020XQ8HQJJTTJDK4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1501113
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