Enrofloxacin, a quinolone antibiotic developed exclusively for use in animals, was investigated for its effects on the steady-state pharmacokinetics of theophylline in six healthy Beagle dogs. A sustained-release theophylline formulation was given alone (20 mg/kg per os twice daily at 12 h intervals) for 9 days and then co-administered with enrofloxacin (5 mg/kg i.v, once a day) for 5 days. Mean trough theophylline concentrations progressively and significantly increased during the five days of enrofloxacin co-administration. Theophylline clearance and concentration-time profile were significantly changed by enrofloxacin co-administration. No significant change was observed in enrofloxacin pharmacokinetics, The kinetic interaction between theophylline and enrofloxacin could be of clinical significance and may require plasma drug concentration monitoring and adjustment of theophylline dosage.

Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the Beagle dog / Intorre, L.; Mengozzi, G.; Maccheroni, M.; Bertini, Simone. - In: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. - ISSN 0140-7783. - 18:(1995), pp. 352-356. [10.1111/j.1365-2885.1995.tb00603.x]

Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the Beagle dog.

BERTINI, Simone
1995-01-01

Abstract

Enrofloxacin, a quinolone antibiotic developed exclusively for use in animals, was investigated for its effects on the steady-state pharmacokinetics of theophylline in six healthy Beagle dogs. A sustained-release theophylline formulation was given alone (20 mg/kg per os twice daily at 12 h intervals) for 9 days and then co-administered with enrofloxacin (5 mg/kg i.v, once a day) for 5 days. Mean trough theophylline concentrations progressively and significantly increased during the five days of enrofloxacin co-administration. Theophylline clearance and concentration-time profile were significantly changed by enrofloxacin co-administration. No significant change was observed in enrofloxacin pharmacokinetics, The kinetic interaction between theophylline and enrofloxacin could be of clinical significance and may require plasma drug concentration monitoring and adjustment of theophylline dosage.
1995
Enrofloxacin-theophylline interaction: influence of enrofloxacin on theophylline steady-state pharmacokinetics in the Beagle dog / Intorre, L.; Mengozzi, G.; Maccheroni, M.; Bertini, Simone. - In: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. - ISSN 0140-7783. - 18:(1995), pp. 352-356. [10.1111/j.1365-2885.1995.tb00603.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1500745
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