HBV genotypes were investigated in sera/plasma from 97 HBV positive subjects. Genotype D was revealed in 80.4% followed by E in 6.2%. Genotypes A, B, and C were also found, as well as for the first time a new combination of HBV D and G genotypes. In a cohort of subjects of this population, the relationship with lamivudine and/or famciclovir-resistant HBV mutants was also investigated. Among 12 untreated subjects, 25% carried HBV drug-resistant strains suggesting that drug-resistant variants naturally exist in untreated Italian HBV chronically infected subjects.
HBV genotypes and antiviral-resistant variants in HBV infected subjects in Northern Italy / Medici, Maria Cristina; Aloisi, A.; Martinelli, M.; Abelli, L. A.; Casula, F.; Valcavi, P.; Dettori, Giuseppe; Chezzi, Carlo. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 29:(2006), pp. 63-67.
HBV genotypes and antiviral-resistant variants in HBV infected subjects in Northern Italy
MEDICI, Maria Cristina;DETTORI, Giuseppe;CHEZZI, Carlo
2006-01-01
Abstract
HBV genotypes were investigated in sera/plasma from 97 HBV positive subjects. Genotype D was revealed in 80.4% followed by E in 6.2%. Genotypes A, B, and C were also found, as well as for the first time a new combination of HBV D and G genotypes. In a cohort of subjects of this population, the relationship with lamivudine and/or famciclovir-resistant HBV mutants was also investigated. Among 12 untreated subjects, 25% carried HBV drug-resistant strains suggesting that drug-resistant variants naturally exist in untreated Italian HBV chronically infected subjects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
