The effect of the beta(3)-adrenoceptor agonist BRL37344 on gastric acid secretion evoked by different secretory stimuli was investigated in anaesthetized rats with lumen-perfused stomachs in comparison with the beta(2)-adrenoceptor agonist clenbuterol. Intravenous injections of BRL37344 (1-10 mumol/kg) and clenbuterol (0.01-1 mumol/kg) dose-dependently reduced 2-deoxy-D-glucose-induced acid secretion, with BRL37344 about forty times less potent than clenbuterol. BRL37344 (0.1-3 mumol/kg) inhibited pentagastrin-induced acid output, whereas clenbuterol was effective only at high doses (10-100 mumol/kg). The inhibitory effect of BRL37344 on pentagastrin-induced acid secretion was not modified by the nonselective beta-adrenoceptor antagonist propranolol, but it was prevented by bupranolol, a beta(3)-adrenoceptor antagonist. Furthermore, neither BRL37344 (10 mumol/kg) nor clenbuterol (100 mumol/kg) modified the acid secretion induced by histamine. These data suggest that beta(3) adrenoceptors have an inhibitory role in the control of rat gastric acid secretion induced by indirect stimuli.
Pharmacological evidence for beta3 adrenoceptors in the control of rat gastric acid secretion / ADAMI M.; CORUZZI G.; SOTIROV E.; BERTINI S.; SOLDANI G.. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - 48(2003), pp. 334-339. [10.1023/A:1021987712677]