The residue depletion of thiamphenicol (TAP) was investigated in the sea-bass (Dicentrarchus labrax) after 5 days' treatment with medicated food at a dose of 15 or 30 mg/kg bw/day. Fish were sampled for blood and muscle + skin from 3 h until 14 days after treatment. Thiamphenicol concentrations were assayed by high performance liquid chromatography. Thiamphenicol concentrations measured 3 h after stopping treatment were 0.77 mug/mL and 0.91 (15 mg/kg dose) or 1.32 mug/mL and 1.47 mug/g (30 mg/kg dose), in plasma and muscle + skin, respectively. After a withdrawal of 3 days, plasma and tissue concentrations were: 0.08 mug/mL and 0.03 mug/g (lower dose) or 0.12 mug/mL and 0.06 mug/g (higher dose), respectively, Thiamphenicol was not detectable either in plasma or in tissues on days 7, 10 and 14 following withdrawal of the medicated food. Based on maximum residue levels (MRL) for TAP in fin fish, established at 50 mug/kg for muscle and skin in natural proportions, a withdrawal period of 5 and 6 days is proposed, after treatment at 15 or 3 0 mg/kg of TAP with medicated feed pellets, respectively, to avoid the presence of violative residues in the edible tissues of the sea-bass.

Residue depletion of thiamphenicol in the sea-bass / Intorre, L.; Castells, G.; Cristofol, C.; Bertini, Simone; Soldani, G.; Arboix, M.. - In: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. - ISSN 0140-7783. - 25:(2002), pp. 59-63. [10.1046/j.1365-2885.2002.00374.x]

Residue depletion of thiamphenicol in the sea-bass

BERTINI, Simone;
2002-01-01

Abstract

The residue depletion of thiamphenicol (TAP) was investigated in the sea-bass (Dicentrarchus labrax) after 5 days' treatment with medicated food at a dose of 15 or 30 mg/kg bw/day. Fish were sampled for blood and muscle + skin from 3 h until 14 days after treatment. Thiamphenicol concentrations were assayed by high performance liquid chromatography. Thiamphenicol concentrations measured 3 h after stopping treatment were 0.77 mug/mL and 0.91 (15 mg/kg dose) or 1.32 mug/mL and 1.47 mug/g (30 mg/kg dose), in plasma and muscle + skin, respectively. After a withdrawal of 3 days, plasma and tissue concentrations were: 0.08 mug/mL and 0.03 mug/g (lower dose) or 0.12 mug/mL and 0.06 mug/g (higher dose), respectively, Thiamphenicol was not detectable either in plasma or in tissues on days 7, 10 and 14 following withdrawal of the medicated food. Based on maximum residue levels (MRL) for TAP in fin fish, established at 50 mug/kg for muscle and skin in natural proportions, a withdrawal period of 5 and 6 days is proposed, after treatment at 15 or 3 0 mg/kg of TAP with medicated feed pellets, respectively, to avoid the presence of violative residues in the edible tissues of the sea-bass.
2002
Residue depletion of thiamphenicol in the sea-bass / Intorre, L.; Castells, G.; Cristofol, C.; Bertini, Simone; Soldani, G.; Arboix, M.. - In: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS. - ISSN 0140-7783. - 25:(2002), pp. 59-63. [10.1046/j.1365-2885.2002.00374.x]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1449518
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 8
social impact