The effects of cannabinoid CB1 receptor activation (HU-210) and blockade (SR141716A) on gastric acid secretion were determined in anaesthetized rats with lumen perfused stomach. The selective CB1-receptor agonist HU-210 (0.01-0-1 mg kg−1, i.v.) did not affect basal acid secretion while causing inhibition (maximum reduction 74%) of the gastric acid secretion stimulated by pentagastrin (10μ kg−1, i.v.). The inhibitory effect of HU-210 was reversed by the selective cannabinoid CB1-receptor antagonist SR141716A (1 mg kg−1, i.v.), but not by the selective CB2-receptor antagonist SR144528 (1 mg kg−1, i.v.). These results suggest that cannabinoid CB1 receptors may mediate inhibitory effects on gastric acid secretion in the rat.

Cannabinoid CB1 receptors are involved in the regulation of rat gastric acid secretion / Adami, Maristella; Bertini, Simone; Frati, P.; Soldani, G.; Coruzzi, G.. - In: PHARMACY AND PHARMACOLOGY COMMUNICATIONS. - ISSN 1460-8081. - 6:(2000), pp. 273-275. [10.1211/146080800128735953]

Cannabinoid CB1 receptors are involved in the regulation of rat gastric acid secretion

ADAMI, Maristella;BERTINI, Simone;
2000-01-01

Abstract

The effects of cannabinoid CB1 receptor activation (HU-210) and blockade (SR141716A) on gastric acid secretion were determined in anaesthetized rats with lumen perfused stomach. The selective CB1-receptor agonist HU-210 (0.01-0-1 mg kg−1, i.v.) did not affect basal acid secretion while causing inhibition (maximum reduction 74%) of the gastric acid secretion stimulated by pentagastrin (10μ kg−1, i.v.). The inhibitory effect of HU-210 was reversed by the selective cannabinoid CB1-receptor antagonist SR141716A (1 mg kg−1, i.v.), but not by the selective CB2-receptor antagonist SR144528 (1 mg kg−1, i.v.). These results suggest that cannabinoid CB1 receptors may mediate inhibitory effects on gastric acid secretion in the rat.
2000
Cannabinoid CB1 receptors are involved in the regulation of rat gastric acid secretion / Adami, Maristella; Bertini, Simone; Frati, P.; Soldani, G.; Coruzzi, G.. - In: PHARMACY AND PHARMACOLOGY COMMUNICATIONS. - ISSN 1460-8081. - 6:(2000), pp. 273-275. [10.1211/146080800128735953]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1449514
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