The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that previously-unknown inhibitors of monoacylglycerol lipase (MGL), a presynaptic enzyme that hydrolyzes 2-AG, increase brain 2-AG levels and enhance retrograde signaling from pyramidal cells to GABAergic axon terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and highlight the significance of MGL as a drug target.
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus / Makara, J. K.; Mor, Marco; Fegley, D.; Szab, S. I.; Kathuria, S.; Astarita, G.; Duranti, A.; Tontini, A.; Tarzia, G.; Rivara, Silvia; Freund, T. F.; Piomelli, D.. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - 8:(2005), pp. 1139-1141. [10.1038/nn1521]
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
MOR, Marco;RIVARA, Silvia;
2005-01-01
Abstract
The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that previously-unknown inhibitors of monoacylglycerol lipase (MGL), a presynaptic enzyme that hydrolyzes 2-AG, increase brain 2-AG levels and enhance retrograde signaling from pyramidal cells to GABAergic axon terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and highlight the significance of MGL as a drug target.| File | Dimensione | Formato | |
|---|---|---|---|
|
2005NN_Makara_MGL.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
233.29 kB
Formato
Adobe PDF
|
233.29 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
