The functions of 2-arachidonoylglycerol (2-AG), the most abundant endocannabinoid found in the brain, remain largely unknown. Here we show that previously-unknown inhibitors of monoacylglycerol lipase (MGL), a presynaptic enzyme that hydrolyzes 2-AG, increase brain 2-AG levels and enhance retrograde signaling from pyramidal cells to GABAergic axon terminals in the hippocampus. These results establish a role for 2-AG in synaptic plasticity and highlight the significance of MGL as a drug target.
|???metadata.dc.ugov.nometipoministero???:||Articolo su rivista|
|Appare nelle tipologie:||1.1 Articolo su rivista|