We report an X-ray reflectivity study on the effects of adsorption of myelin basic protein (MBP) on Langmuir monolayers and on deposited Langmuir– Schaefer multilayers of the phospholipid dipalmitoyl phosphatidylglycerol (DPPG). We provide for the first time, direct microscopic evidence on the destructuring effects of MBP leading to plasticity of the DPPG layers supporting commonly accepted models of the stabilizing role of MBP in the myelin membrane. We also show how protein adsorption onto the layer is determined both by electrostatic and nonspecific hydrophobic interactions.
Micro-structural analysis of the effects of incorporation of Myelin Basic Protein in phospholipid layers / Cristofolini, Luigi; Fontana, Marco Paolo; F., Serra; A., Fasano; P., Riccio; O., Konovalov. - In: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. - ISSN 0175-7571. - 34:(2005), pp. 1041-1048. [10.1007/s00249-005-0489-5]
Micro-structural analysis of the effects of incorporation of Myelin Basic Protein in phospholipid layers
CRISTOFOLINI, Luigi;FONTANA, Marco Paolo;
2005-01-01
Abstract
We report an X-ray reflectivity study on the effects of adsorption of myelin basic protein (MBP) on Langmuir monolayers and on deposited Langmuir– Schaefer multilayers of the phospholipid dipalmitoyl phosphatidylglycerol (DPPG). We provide for the first time, direct microscopic evidence on the destructuring effects of MBP leading to plasticity of the DPPG layers supporting commonly accepted models of the stabilizing role of MBP in the myelin membrane. We also show how protein adsorption onto the layer is determined both by electrostatic and nonspecific hydrophobic interactions.| File | Dimensione | Formato | |
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