A new series of ligands is synthesised starting from thiocarbonohydrazide and isatin (H2itc) or N-alkylisatin (methyl, H2mtc; butyl, H2btc; pentyl, H2ptc); the X-ray structure of H2mtc is discussed. The bis imine ligands are reacted with diorganotin(IV) compounds, obtaining monometallic complexes. In order to establish unequivocally their coordination geometry, the X-ray structures of (C2H5)2Sn(Hmtc)Cl Æ THF (THF, tetrahydrofuran) and (C6H5)Sn(Hptc)Cl2 are determined. In (C2H5)2Sn(Hmtc)Cl Æ THF, the ligand results monodeprotonated and, essentially, monodentate through the sulphur atom, while in (C6H5)Sn(Hptc)Cl2 the ligand is still monodeprotonated but SNO tridentate. The organotin(IV) complexes of isatin and N-methylisatin exhibit good antibacterial activity, better than that of the corresponding N-butyl and N-pentylisatin derivatives. Gram positive bacteria are the most sensitive microorganisms. No growth inhibition of fungi is detected up to the concentration of 100 lg/ml. H2mtc shows mutagenic activity with and without metabolic activation, whereas no mutagenicity is found for its organotin complexes and for the other compounds.

Antimicrobial and mutagenic properties of organotin(IV) complexes with isatin and N-alkylisatin bisthiocarbonohydrazones / Bacchi, Alessia; Carcelli, Mauro; Pelagatti, Paolo; Pelizzi, Giancarlo; RODRIGUEZ ARGUELLES, M. C.; Rogolino, Dominga; Solinas, C.; Zani, Franca. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 99:(2005), pp. 397-408. [10.1016/j.jinorgbio.2004.10.008]

Antimicrobial and mutagenic properties of organotin(IV) complexes with isatin and N-alkylisatin bisthiocarbonohydrazones

BACCHI, Alessia;CARCELLI, Mauro;PELAGATTI, Paolo;PELIZZI, Giancarlo;ROGOLINO, Dominga;ZANI, Franca
2005-01-01

Abstract

A new series of ligands is synthesised starting from thiocarbonohydrazide and isatin (H2itc) or N-alkylisatin (methyl, H2mtc; butyl, H2btc; pentyl, H2ptc); the X-ray structure of H2mtc is discussed. The bis imine ligands are reacted with diorganotin(IV) compounds, obtaining monometallic complexes. In order to establish unequivocally their coordination geometry, the X-ray structures of (C2H5)2Sn(Hmtc)Cl Æ THF (THF, tetrahydrofuran) and (C6H5)Sn(Hptc)Cl2 are determined. In (C2H5)2Sn(Hmtc)Cl Æ THF, the ligand results monodeprotonated and, essentially, monodentate through the sulphur atom, while in (C6H5)Sn(Hptc)Cl2 the ligand is still monodeprotonated but SNO tridentate. The organotin(IV) complexes of isatin and N-methylisatin exhibit good antibacterial activity, better than that of the corresponding N-butyl and N-pentylisatin derivatives. Gram positive bacteria are the most sensitive microorganisms. No growth inhibition of fungi is detected up to the concentration of 100 lg/ml. H2mtc shows mutagenic activity with and without metabolic activation, whereas no mutagenicity is found for its organotin complexes and for the other compounds.
Antimicrobial and mutagenic properties of organotin(IV) complexes with isatin and N-alkylisatin bisthiocarbonohydrazones / Bacchi, Alessia; Carcelli, Mauro; Pelagatti, Paolo; Pelizzi, Giancarlo; RODRIGUEZ ARGUELLES, M. C.; Rogolino, Dominga; Solinas, C.; Zani, Franca. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 99:(2005), pp. 397-408. [10.1016/j.jinorgbio.2004.10.008]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1443726
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