ABSTRACT. We report an 8-year-old girl who presented with clinical features of an acute myocardial infarction. The angiographic appearance of the coronary arteries was normal. A thrombophilic state caused by a homozygote genotype for the prothrombin G20210A mutation was detected, and a patent foramen ovale (PFO) with right-to-left shunting after Valsalva maneuver was demonstrated by transesophageal contrast echocardiography. No other embolic source was identified. We suggest that paradoxical embolization through a PFO resulted in a myocardial infarction in this young patient with hereditary thrombophilia. We closed the patient’s PFO with a 25-mm PFO occluder. She was anticoagulated with warfarin for 6 months. After 6 months, a contrast echocardiogram showed no evidence of residual atrial shunt. There has been no evident recurrent paradoxical embolization. Pediatrics 2004;114:e255–e258. URL: http: //www.pediatrics.org/cgi/content/full/114/2/e255; myocardial infarction, patent foramen ovale, hypercoagulable state, prothrombin G20210A, paradoxic embolism.

Acute myocardial infarction in a child: possible pathogenic role of patent foramen ovale associated with heritable thrombophilia / Carano, Nicola; Agnetti, Aldo; Hagler, Dj; Tchana, B; Squarcia, U; Bernasconi, Sergio. - In: PEDIATRICS. - ISSN 0079-0400. - 114(2):(2004), pp. e255-e258. [10.1542/peds.114.2.e255]

Acute myocardial infarction in a child: possible pathogenic role of patent foramen ovale associated with heritable thrombophilia

CARANO, Nicola;AGNETTI, Aldo;BERNASCONI, Sergio
2004-01-01

Abstract

ABSTRACT. We report an 8-year-old girl who presented with clinical features of an acute myocardial infarction. The angiographic appearance of the coronary arteries was normal. A thrombophilic state caused by a homozygote genotype for the prothrombin G20210A mutation was detected, and a patent foramen ovale (PFO) with right-to-left shunting after Valsalva maneuver was demonstrated by transesophageal contrast echocardiography. No other embolic source was identified. We suggest that paradoxical embolization through a PFO resulted in a myocardial infarction in this young patient with hereditary thrombophilia. We closed the patient’s PFO with a 25-mm PFO occluder. She was anticoagulated with warfarin for 6 months. After 6 months, a contrast echocardiogram showed no evidence of residual atrial shunt. There has been no evident recurrent paradoxical embolization. Pediatrics 2004;114:e255–e258. URL: http: //www.pediatrics.org/cgi/content/full/114/2/e255; myocardial infarction, patent foramen ovale, hypercoagulable state, prothrombin G20210A, paradoxic embolism.
Acute myocardial infarction in a child: possible pathogenic role of patent foramen ovale associated with heritable thrombophilia / Carano, Nicola; Agnetti, Aldo; Hagler, Dj; Tchana, B; Squarcia, U; Bernasconi, Sergio. - In: PEDIATRICS. - ISSN 0079-0400. - 114(2):(2004), pp. e255-e258. [10.1542/peds.114.2.e255]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1441538
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