Nickel, copper, and zinc complexes of isatin (H2L1) and N-methylisatin 3-picolinoyl hydrazone (HL2), were synthesized and characterized by means of spectroscopic techniques. H2L1 and a nickel complex [Ni(L2)2] 2C6H14 were also characterized by X-ray diffractometry. Biological studies, carried out in vitro on human leukemic cell lines TOM 1 and NB4, have shown that both ligands and some copper and nickel complexes are active in inhibiting cell proliferation. Compounds H2L1, Cu(HL1)2 2H2O, Zn(HL1)2 2H2O inhibit DNA synthesis and act constantly with time between 0 and 72 h. The cell cycle analysis has highlighted a reduction in the number of cells in phase S of about 40%. The same compounds present only a precocious action on cell line NB4 and therefore their activity is cell target specific.

Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones / RODRIGUEZ ARGUELLES, M. C.; Ferrari, Marisa; Bisceglie, Franco; Pelizzi, Corrado; Pelosi, Giorgio; Pinelli, Silvana; Sassi, Monica. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 98:(2004), pp. 313-321. [10.1016/j.jinorgbio.2003.10.006]

Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones

FERRARI, Marisa;BISCEGLIE, Franco;PELIZZI, CORRADO;PELOSI, Giorgio;PINELLI, Silvana;SASSI, Monica
2004-01-01

Abstract

Nickel, copper, and zinc complexes of isatin (H2L1) and N-methylisatin 3-picolinoyl hydrazone (HL2), were synthesized and characterized by means of spectroscopic techniques. H2L1 and a nickel complex [Ni(L2)2] 2C6H14 were also characterized by X-ray diffractometry. Biological studies, carried out in vitro on human leukemic cell lines TOM 1 and NB4, have shown that both ligands and some copper and nickel complexes are active in inhibiting cell proliferation. Compounds H2L1, Cu(HL1)2 2H2O, Zn(HL1)2 2H2O inhibit DNA synthesis and act constantly with time between 0 and 72 h. The cell cycle analysis has highlighted a reduction in the number of cells in phase S of about 40%. The same compounds present only a precocious action on cell line NB4 and therefore their activity is cell target specific.
2004
Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones / RODRIGUEZ ARGUELLES, M. C.; Ferrari, Marisa; Bisceglie, Franco; Pelizzi, Corrado; Pelosi, Giorgio; Pinelli, Silvana; Sassi, Monica. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 98:(2004), pp. 313-321. [10.1016/j.jinorgbio.2003.10.006]
File in questo prodotto:
File Dimensione Formato  
Journal of Inorganic Biochemistry 2 (2004) 313-321.pdf

non disponibili

Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 505.07 kB
Formato Adobe PDF
505.07 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1441358
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 202
  • ???jsp.display-item.citation.isi??? 191
social impact