The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimental models as well as humans, to cause morphological changes in the developing nervous system. Chemicals that are discussed include methylmercury (MeHg), lead (Pb), antiepileptic drugs, and ethanol. Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed.

Developmental neuropathology of environmental agents / Costa, Lucio Guido; Aschner, M.; Vitalone, A.; Syversen, T.; Poratsoldin, O.. - In: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. - ISSN 0362-1642. - 44:(2004), pp. 87-110. [10.1146/annurev.pharmtox.44.101802.121424]

Developmental neuropathology of environmental agents

COSTA, Lucio Guido;
2004-01-01

Abstract

The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimental models as well as humans, to cause morphological changes in the developing nervous system. Chemicals that are discussed include methylmercury (MeHg), lead (Pb), antiepileptic drugs, and ethanol. Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed.
2004
Developmental neuropathology of environmental agents / Costa, Lucio Guido; Aschner, M.; Vitalone, A.; Syversen, T.; Poratsoldin, O.. - In: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. - ISSN 0362-1642. - 44:(2004), pp. 87-110. [10.1146/annurev.pharmtox.44.101802.121424]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1440976
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