The present invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, non-agglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%). Licenza concessa alla ditta Lisapharma di Erba (CO) da parte dell'Università degli Studi di Parma

INSULIN HIGHLY RESPIRABLE MICROPARTICLES / Colombo, Paolo; Cagnani, Stefano; Ventura, P.. - (2004).

INSULIN HIGHLY RESPIRABLE MICROPARTICLES

COLOMBO, Paolo;CAGNANI, Stefano;
2004-01-01

Abstract

The present invention describes novel dried powders of peptide therapeutic agent useful for producing highly respirable aerosols and the methods for their manufacture. Insulin is the peptide therapeutic agent in the preferred embodiment. The powders of insulin prepared for pulmonary administration are characterized by the peculiar structure and shape of the microparticles that allow the powder to flow and to be easy aerosolized. Typical dry powder of insulin described in this patent show corrugated, non-agglomerated microparticles with a low tapped density. The mean geometric diameter (particle size) ranges between 1.0 and 10.0 micron and the mass median aerodynamic diameter (MMAD) ranges between 1.0 and 4.0 micron. These insulin pulmonary powders exhibit in vitro a very high respirable fraction (>75%). Licenza concessa alla ditta Lisapharma di Erba (CO) da parte dell'Università degli Studi di Parma
2004
INSULIN HIGHLY RESPIRABLE MICROPARTICLES / Colombo, Paolo; Cagnani, Stefano; Ventura, P.. - (2004).
File in questo prodotto:
File Dimensione Formato  
JP4792457B2.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: Creative commons
Dimensione 85.85 kB
Formato Adobe PDF
85.85 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
EP1734938 Intention to grant in Europe.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: Creative commons
Dimensione 805.28 kB
Formato Adobe PDF
805.28 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Product ID 1440674.doc

non disponibili

Tipologia: Abstract
Licenza: Creative commons
Dimensione 23.5 kB
Formato Microsoft Word
23.5 kB Microsoft Word   Visualizza/Apri   Richiedi una copia
US7625865B2.pdf

non disponibili

Tipologia: Altro materiale allegato
Licenza: Creative commons
Dimensione 576.16 kB
Formato Adobe PDF
576.16 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1440674
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact