ANNUNZIATO, Giannamaria
ANNUNZIATO, Giannamaria
Dipartimento di Scienze degli Alimenti e del Farmaco
2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry
2020-01-01 Azzali, E.; Girardini, M.; Annunziato, G.; Pavone, M.; Vacondio, F.; Mori, G.; Pasca, M. R.; Costantino, G.; Pieroni, M.
A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex
2021-01-01 Marchetti, M.; De Angelis, F. S.; Annunziato, G.; Costantino, G.; Pieroni, M.; Ronda, L.; Mozzarelli, A.; Campanini, B.; Cannistraro, S.; Bizzarri, A. R.; Bettati, S.
Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents
2017-01-01 Pieroni, Marco; Azzali, Elisa; Basilico, Nicoletta; Parapini, Silvia; Zolkiewski, Michal; Beato, Claudia; Annunziato, Giannamaria; Bruno, Agostino; Vacondio, Federica; Costantino, Gabriele
Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes
2018-01-01 Giovati, Laura; Annunziato, Giannamaria; Ciociola, Tecla; Magliani, Valter; Polonelli, Luciano; Conti, Stefania; Supuran, Claudiu T.; Costantino, Gabriele
Antimicrobial peptides (AMPs): a patent review (2015-2020)
2020-01-01 Annunziato, Giannamaria; Costantino, Gabriele
Biochemical characterization of Aspergillus fumigatus AroH, a putative aromatic amino acid aminotransferase
2018-01-01 Dindo, Mirco; Costanzi, Egidia; Pieroni, Marco; Costantini, Claudio; Annunziato, Giannamaria; Bruno, Agostino; Keller, Nancy P.; Romani, Luigina; Zelante, Teresa; Cellini, Barbara
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR
2016-01-01 Annunziato, Giannamaria; Pieroni, Marco; Benoni, Roberto; Campanini, Barbara; Pertinhez, Thelma; Pecchini, Chiara; Bruno, Agostino; Magalhães, Joana; Bettati, Stefano; Franko, Nina; Mozzarelli, Andrea; Costantino, Gabriele
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1
2019-01-01 Dindo, M.; Grottelli, S.; Annunziato, G.; Giardina, G.; Pieroni, M.; Pampalone, G.; Faccini, A.; Cutruzzola, F.; Laurino, P.; Costantino, G.; Cellini, B.
Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases
2018-01-01 Annunziato, Giannamaria; Giovati, Laura; Andrea, Angeli; Pavone, Marialaura; Sonia Del Prete, ; Pieroni, Marco; Clemente, Capasso; Bruno, Agostino; Conti, Stefania; Magliani, Valter; Supuran, Claudiu T.; Costantino, Gabriele
Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches
2016-01-01 Annunziato, Giannamaria; Angeli, Andrea; D'Alba, Francesca; Bruno, Agostino; Pieroni, Marco; Vullo, Daniela; De Luca, Viviana; Capasso, Clemente; Supuran, Claudiu T.; Costantino, Gabriele
Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design
2018-01-01 Magalhães, Joana; Franko, Nina; Annunziato, Giannamaria; Welch, Martin; Dolan, Stephen K.; Bruno, Agostino; Mozzarelli, Andrea; Armao, Stefano; Jirgensons, Aigars; Pieroni, Marco; Costantino, Gabriele; Campanini, Barbara
Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants
2021-01-01 Magalhães, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Päivi; Bruno, Agostino; Bettati, Stefano; Armao, Stefano; Spadini, Costanza; Cabassi, Clotilde Silvia; Mozzarelli, Andrea; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization
2022-01-01 Girardini, Miriam; Ferlenghi, Francesca; Annunziato, Giannamaria; Degiacomi, Giulia; Papotti, Bianca; Marchi, Cinzia; Camilla Sammartino, José; S Rasheed, Sari; Contini, Anna; Rosalia Pasca, Maria; Vacondio, Federica; C Evans, Joanna; Dick, Thomas; Müller, Rolf; Costantino, Gabriele; Pieroni, Marco
Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties
2022-01-01 Pavone, M.; Raboni, S.; Marchetti, M.; Annunziato, G.; Bettati, S.; Papotti, B.; Marchi, C.; Carosati, E.; Pieroni, M.; Campanini, B.; Costantino, G.
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A
2015-01-01 Pieroni, Marco; Annunziato, Giannamaria; Azzali, Elisa; Dessanti, Paola; Mercurio, Ciro; Meroni, Giuseppe; Trifiró, Paolo; Vianello, Paola; Villa, Manuela; Beato, Claudia; Varasi, Mario; Costantino, Gabriele
Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1
2022-01-01 Grottelli, Silvia; Annunziato, Giannamaria; Pampalone, Gioena; Pieroni, Marco; Dindo, Mirco; Ferlenghi, Francesca; Costantino, Gabriele; Cellini, Barbara
In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility
2018-01-01 Annunziato, Giannamaria; Falavigna, Claudia; Pieroni, Marco; Faccini, Andrea; Micheli, Fabrizio; Costantino, Gabriele
Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor
2020-01-01 Magalhaes, J.; Franko, N.; Raboni, S.; Annunziato, G.; Tammela, P.; Bruno, A.; Bettati, S.; Mozzarelli, A.; Pieroni, M.; Campanini, B.; Costantino, G.
Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria
2022-01-01 Annunziato, Giannamaria; Spadini, Costanza; Marchetti, Marialaura; Franko, Nina; Pavone, Marialaura; Iannarelli, Mattia; Bruno, Agostino; Pieroni, Marco; Bettati, Stefano; Cabassi, Clotilde Silvia; Campanini, Barbara; Costantino, Gabriele
Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets
2018-01-01 Magalhães, Joana; Annunziato, Giannamaria; Franko, Nina; Pieroni, Marco; Campanini, Barbara; Bruno, Agostino; Costantino, Gabriele
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry | 1-gen-2020 | Azzali, E.; Girardini, M.; Annunziato, G.; Pavone, M.; Vacondio, F.; Mori, G.; Pasca, M. R.; Costantino, G.; Pieroni, M. | |
| A competitive o‐acetylserine sulfhydrylase inhibitor modulates the formation of cysteine synthase complex | 1-gen-2021 | Marchetti, M.; De Angelis, F. S.; Annunziato, G.; Costantino, G.; Pieroni, M.; Ronda, L.; Mozzarelli, A.; Campanini, B.; Cannistraro, S.; Bizzarri, A. R.; Bettati, S. | |
| Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents | 1-gen-2017 | Pieroni, Marco; Azzali, Elisa; Basilico, Nicoletta; Parapini, Silvia; Zolkiewski, Michal; Beato, Claudia; Annunziato, Giannamaria; Bruno, Agostino; Vacondio, Federica; Costantino, Gabriele | |
| Antifungal properties of newly designed carbonic anhydrases inhibitors selective for microbial enzymes | 1-gen-2018 | Giovati, Laura; Annunziato, Giannamaria; Ciociola, Tecla; Magliani, Valter; Polonelli, Luciano; Conti, Stefania; Supuran, Claudiu T.; Costantino, Gabriele | |
| Antimicrobial peptides (AMPs): a patent review (2015-2020) | 1-gen-2020 | Annunziato, Giannamaria; Costantino, Gabriele | |
| Biochemical characterization of Aspergillus fumigatus AroH, a putative aromatic amino acid aminotransferase | 1-gen-2018 | Dindo, Mirco; Costanzi, Egidia; Pieroni, Marco; Costantini, Claudio; Annunziato, Giannamaria; Bruno, Agostino; Keller, Nancy P.; Romani, Luigina; Zelante, Teresa; Cellini, Barbara | |
| Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR | 1-gen-2016 | Annunziato, Giannamaria; Pieroni, Marco; Benoni, Roberto; Campanini, Barbara; Pertinhez, Thelma; Pecchini, Chiara; Bruno, Agostino; Magalhães, Joana; Bettati, Stefano; Franko, Nina; Mozzarelli, Andrea; Costantino, Gabriele | |
| Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: Implications for Primary Hyperoxaluria type 1 | 1-gen-2019 | Dindo, M.; Grottelli, S.; Annunziato, G.; Giardina, G.; Pieroni, M.; Pampalone, G.; Faccini, A.; Cutruzzola, F.; Laurino, P.; Costantino, G.; Cellini, B. | |
| Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases | 1-gen-2018 | Annunziato, Giannamaria; Giovati, Laura; Andrea, Angeli; Pavone, Marialaura; Sonia Del Prete, ; Pieroni, Marco; Clemente, Capasso; Bruno, Agostino; Conti, Stefania; Magliani, Valter; Supuran, Claudiu T.; Costantino, Gabriele | |
| Discovery of New Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focused Repurposing Approaches | 1-gen-2016 | Annunziato, Giannamaria; Angeli, Andrea; D'Alba, Francesca; Bruno, Agostino; Pieroni, Marco; Vullo, Daniela; De Luca, Viviana; Capasso, Clemente; Supuran, Claudiu T.; Costantino, Gabriele | |
| Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design | 1-gen-2018 | Magalhães, Joana; Franko, Nina; Annunziato, Giannamaria; Welch, Martin; Dolan, Stephen K.; Bruno, Agostino; Mozzarelli, Andrea; Armao, Stefano; Jirgensons, Aigars; Pieroni, Marco; Costantino, Gabriele; Campanini, Barbara | |
| Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants | 1-gen-2021 | Magalhães, Joana; Franko, Nina; Raboni, Samanta; Annunziato, Giannamaria; Tammela, Päivi; Bruno, Agostino; Bettati, Stefano; Armao, Stefano; Spadini, Costanza; Cabassi, Clotilde Silvia; Mozzarelli, Andrea; Pieroni, Marco; Campanini, Barbara; Costantino, Gabriele | |
| Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit–to–lead optimization and release of a novel antitubercular chemotype via scaffold derivatization | 1-gen-2022 | Girardini, Miriam; Ferlenghi, Francesca; Annunziato, Giannamaria; Degiacomi, Giulia; Papotti, Bianca; Marchi, Cinzia; Camilla Sammartino, José; S Rasheed, Sari; Contini, Anna; Rosalia Pasca, Maria; Vacondio, Federica; C Evans, Joanna; Dick, Thomas; Müller, Rolf; Costantino, Gabriele; Pieroni, Marco | |
| Exploring the chemical space around N-(5-nitrothiazol-2-yl)-1,2,3-thiadiazole-4-carboxamide, a hit compound with serine acetyltransferase (SAT) inhibitory properties | 1-gen-2022 | Pavone, M.; Raboni, S.; Marchetti, M.; Annunziato, G.; Bettati, S.; Papotti, B.; Marchi, C.; Carosati, E.; Pieroni, M.; Campanini, B.; Costantino, G. | |
| Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A | 1-gen-2015 | Pieroni, Marco; Annunziato, Giannamaria; Azzali, Elisa; Dessanti, Paola; Mercurio, Ciro; Meroni, Giuseppe; Trifiró, Paolo; Vianello, Paola; Villa, Manuela; Beato, Claudia; Varasi, Mario; Costantino, Gabriele | |
| Identification of Human Alanine-Glyoxylate Aminotransferase Ligands as Pharmacological Chaperones for Variants Associated with Primary Hyperoxaluria Type 1 | 1-gen-2022 | Grottelli, Silvia; Annunziato, Giannamaria; Pampalone, Gioena; Pieroni, Marco; Dindo, Mirco; Ferlenghi, Francesca; Costantino, Gabriele; Cellini, Barbara | |
| In vitro digestion of zingiber officinale extract and evaluation of stability as a first step to determine its bioaccesibility | 1-gen-2018 | Annunziato, Giannamaria; Falavigna, Claudia; Pieroni, Marco; Faccini, Andrea; Micheli, Fabrizio; Costantino, Gabriele | |
| Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O-Acetyltransferase Inhibitor | 1-gen-2020 | Magalhaes, J.; Franko, N.; Raboni, S.; Annunziato, G.; Tammela, P.; Bruno, A.; Bettati, S.; Mozzarelli, A.; Pieroni, M.; Campanini, B.; Costantino, G. | |
| Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria | 1-gen-2022 | Annunziato, Giannamaria; Spadini, Costanza; Marchetti, Marialaura; Franko, Nina; Pavone, Marialaura; Iannarelli, Mattia; Bruno, Agostino; Pieroni, Marco; Bettati, Stefano; Cabassi, Clotilde Silvia; Campanini, Barbara; Costantino, Gabriele | |
| Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets | 1-gen-2018 | Magalhães, Joana; Annunziato, Giannamaria; Franko, Nina; Pieroni, Marco; Campanini, Barbara; Bruno, Agostino; Costantino, Gabriele |