ABELTINO, Manuela
ABELTINO, Manuela
Dipartimento di Medicina e Chirurgia
Are the Myeloma bone microevironment cells tumoral or not?
2009-01-01 Giuliani, Nicola; Novara, F; Todoerti, K; Zaffaroni, N; Villa, R; Storti, Paola; Bernardo, Me; Manferdini, C; Gabusi, E; Abeltino, Manuela; Bolzoni, Marina; Agnelli, L; Rocci, A; Colla, S; Sammarelli, Gabriella; Rizzoli, Vittorio; Zuffardi, O; Neri, A; Lisignoli, G.
CC-4047 (Pomalidomide) inhibits multiple myeloma-induced osteoclast formation targeting RANKL in the bone marrow microenvironment
2010-01-01 Giuliani, Nicola; Bolzoni, Marina; Abeltino, Manuela; Storti, Paola; Sgobba, V; Bonomini, S; Pariyyarath, R; Rizzoli, Vittorio
Functional interplay between NIK and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma
2019-01-01 Mazzera, Laura; Abeltino, Manuela; Lombardi, Guerino; Cantoni, Anna Maria; Ria, Roberto; Ricca, Micaela; Saltarella, Ilaria; Naponelli, Valeria; Rizzi, Federica Maria Angela; Perris, Roberto; Corradi, Attilio; Vacca, Angelo; Bonati, Antonio; Lunghi, Paolo
HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients
2011-01-01 Storti, Paola; Donofrio, Gaetano; Colla, S; Airoldi, I; Bolzoni, Marina; Agnelli, L; Abeltino, Manuela; Todoerti, K; Lazzaretti, Mirca; Mancini, C; Ribatti, D; Bonomini, S; Franceschi, Valentina; Pistoia, V; Lisignoli, G; Pedrazzini, A; Cavicchi, O; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola
HOXB7 is a key gene involved in Myeloma cell growth and Myeloma-induced angiogenesis in Multiple Myeloma patients
2009-01-01 Storti, Paola; Colla, S; Donofrio, Gaetano; Airoldi, I; Lazzaretti, Mirca; Todoerti, K; Agnelli, L; Bonomini, S; Bolzoni, Marina; Abeltino, Manuela; Mancini, C; Sammarelli, Gabriella; Lambertenghi Deliliers, G; Neri, A; Pistoia, V; Rizzoli, Vittorio; Giuliani, Nicola
HOXB7 is critically involved in Multiple Myeloma-induced angiogenic switch
2009-01-01 Storti, Paola; Donofrio, Gaetano; Bolzoni, Marina; Colla, S; Airoldi, I; Sgobba, V; Abeltino, Manuela; Todoerti, K; Agnelli, L; Lazzaretti, Mirca; Mancini, C; Bonomini, S; Ribatti, D; Pistoia, V; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola
In vitro and In vivo evidences of osteocytes involvement in myeloma-induced osteolysis
2010-01-01 Giuliani, Nicola; Storti, Paola; Abeltino, Manuela; Bolzoni, Marina; Ferretti, M; Lazzaretti, Mirca; Dalla Palma, B; Todoerti, K; Martella, E; Agnelli, L; Neri, A; Rizzoli, Vittorio; Palumbo, C.
Increased osteocyte apoptosis in Multiple Myeloma patients: a potential role in bone remodeling alterations related to osteolytic bone lesions
2009-01-01 Giuliani, Nicola; Ferretti, M; Abeltino, Manuela; Mancini, C; Martella, E; Dalla Palma, B; Bolzoni, Marina; Sgobba, V; Storti, Paola; Rizzoli, Vittorio; Palumbo, C.
MEK-INHIBITORS/ARSENIC TRIOXIDE COMBINATION THERAPY AS A NOVEL TREATMENT OPTION FOR TYROSINE KINASE INHIBITORS-RESISTANT PH plus -LEUKEMIA
2020-01-01 Mazzera, Laura; Abeltino, Manuela; Lombardi, Guerino; Cantoni, Anna Maria; Jottini, Stefano; Corradi, Attilio; Ricca, Micaela; Arienti, Davide; Peli, Angelo; Perris, Roberto; Bonati, Antonio; Lunghi, Paolo
MEK-INHIBITORS/ARSENIC TRIOXIDE COMBINATION THERAPY AS A NOVEL TREATMENT OPTION FOR TYROSINE KINASE INHIBITORS-RESISTANT PH+-LEUKEMIA
2020-01-01 Mazzera, L.; Abeltino, M.; Lombardi, G.; Cantoni, A. M.; Jottini, S.; Corradi, A.; Ricca, M.; Arienti, D.; Peli, A.; Perris, R.; Bonati, A.; Lunghi, P.
MEK1/2 KINASES DISABLE THE TUMOR SUPPRESSOR FUNCTIONS OF NATIVE BCR AND ABL1 KINASES TO IMPAIR ANTICANCER DRUGS’ RESPONSIVENESS IN TKI-RESISTANT PHILADELPHIA POSITIVE LEUKEMIAS
2024-01-01 Mazzera, L.; Abeltino, M.; Lombardi, G.; Cantoni, A. M.; Jottini, S.; Corradi, A.; Ricca, M.; Rossetti, E.; Armando, F.; Peli, A.; Ferrari, A.; Martinelli, G.; Scupoli, M. T.; Visco, C.; Bonifacio, M.; Ripamonti, A.; Gambacorti-Passerini, C.; Bonati, A.; Perris, R.; Lunghi, P.
MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia
2023-01-01 Mazzera, Laura; Abeltino, Manuela; Lombardi, Guerino; Cantoni, Anna Maria; Jottini, Stefano; Corradi, Attilio; Ricca, Micaela; Rossetti, Elena; Armando, Federico; Peli, Angelo; Ferrari, Anna; Martinelli, Giovanni; Teresa Scupoli, Maria; Visco, Carlo; Bonifacio, Massimiliano; Ripamonti, Alessia; Gambacorti-Passerini, Carlo; Bonati, Antonio; Perris, Roberto; Lunghi, Paolo
Myeloma cells inhibit the non-canonical wnt co-receptor ror2 in human mesenchymal/osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on mm-induced impairment of the osteogenic differentiation process
2009-01-01 Bolzoni, Marina; Colla, S; Storti, Paola; Donofrio, Gaetano; Abeltino, Manuela; Sgobba, V; Bonomini, S; Rizzoli, Vittorio; Giuliani, Nicola
Non canonical wnt signal pathway (Wnt5a/ror2) activation stimulates the osteogenic differentiation process of bone mesenchymal cells being a potential target in multiple myeloma bone disease
2010-01-01 Bolzoni, Marina; Storti, Paola; Donofrio, Gaetano; Abeltino, Manuela; Colla, S; Bonomini, S; Rizzoli, Vittorio; Giuliani, Nicola
Oxygen tension in the bone marrow (BM) of patients with malignant and indolent monoclonal gammopathy: role of hypoxia and hypoxia-inducible factor (HIF)-1{alpha} in the regulation of gene expression and pro-angiogenic profiles of CD138+ cells
2009-01-01 Giuliani, Nicola; Colla, S; Storti, Paola; Sgobba, V; Todoerti, K; Donofrio, Gaetano; Bolzoni, Marina; Abeltino, Manuela; Lazzaretti, Mirca; Bonomini, S; Crugnola, M; Neri, A; Rizzoli, Vittorio
The homeobox gene HOXB7 regulates the production of pro-angiogenic molecole by myeloma cells and it is a target in myeloma-induced angiogenesis
2010-01-01 Storti, Paola; Donofrio, Gaetano; Bolzoni, Marina; Abeltino, Manuela; Colla, S; Airoldi, I; Todoerti, K; Agnelli, L; Lazzaretti, Mirca; Bonomini, S; Dalla Palma, B; Sammarelli, Gabriella; Ribatti, D; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola
The IMID CC-4047 (Pomalidomide) inhibits myeloma-induced osteoclast formation
2010-01-01 Abeltino, Manuela; Bolzoni, Marina; Storti, Paola; Bonomini, S; Pariyyarath, R; Rizzoli, Vittorio; Giuliani, Nicola
The Immunomodulatory drugs Lenalidomide and Pomalidomide inhibit multiple myeloma-induced osteoclast formation and RANKL/OPG ratio in myeloma microenvironment targeting the expression of adhesion molecules
2010-01-01 Bolzoni, Marina; Abeltino, Manuela; Storti, Paola; Bonomini, S; Agnelli, L; Todoerti, K; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola
The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways
2017-01-01 Mazzera, L; Abeltino, M; Bonati, A; Lunghi, P
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Are the Myeloma bone microevironment cells tumoral or not? | 1-gen-2009 | Giuliani, Nicola; Novara, F; Todoerti, K; Zaffaroni, N; Villa, R; Storti, Paola; Bernardo, Me; Manferdini, C; Gabusi, E; Abeltino, Manuela; Bolzoni, Marina; Agnelli, L; Rocci, A; Colla, S; Sammarelli, Gabriella; Rizzoli, Vittorio; Zuffardi, O; Neri, A; Lisignoli, G. | |
| CC-4047 (Pomalidomide) inhibits multiple myeloma-induced osteoclast formation targeting RANKL in the bone marrow microenvironment | 1-gen-2010 | Giuliani, Nicola; Bolzoni, Marina; Abeltino, Manuela; Storti, Paola; Sgobba, V; Bonomini, S; Pariyyarath, R; Rizzoli, Vittorio | |
| Functional interplay between NIK and c-Abl kinases limits response to Aurora inhibitors in multiple myeloma | 1-gen-2019 | Mazzera, Laura; Abeltino, Manuela; Lombardi, Guerino; Cantoni, Anna Maria; Ria, Roberto; Ricca, Micaela; Saltarella, Ilaria; Naponelli, Valeria; Rizzi, Federica Maria Angela; Perris, Roberto; Corradi, Attilio; Vacca, Angelo; Bonati, Antonio; Lunghi, Paolo | |
| HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients | 1-gen-2011 | Storti, Paola; Donofrio, Gaetano; Colla, S; Airoldi, I; Bolzoni, Marina; Agnelli, L; Abeltino, Manuela; Todoerti, K; Lazzaretti, Mirca; Mancini, C; Ribatti, D; Bonomini, S; Franceschi, Valentina; Pistoia, V; Lisignoli, G; Pedrazzini, A; Cavicchi, O; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola | |
| HOXB7 is a key gene involved in Myeloma cell growth and Myeloma-induced angiogenesis in Multiple Myeloma patients | 1-gen-2009 | Storti, Paola; Colla, S; Donofrio, Gaetano; Airoldi, I; Lazzaretti, Mirca; Todoerti, K; Agnelli, L; Bonomini, S; Bolzoni, Marina; Abeltino, Manuela; Mancini, C; Sammarelli, Gabriella; Lambertenghi Deliliers, G; Neri, A; Pistoia, V; Rizzoli, Vittorio; Giuliani, Nicola | |
| HOXB7 is critically involved in Multiple Myeloma-induced angiogenic switch | 1-gen-2009 | Storti, Paola; Donofrio, Gaetano; Bolzoni, Marina; Colla, S; Airoldi, I; Sgobba, V; Abeltino, Manuela; Todoerti, K; Agnelli, L; Lazzaretti, Mirca; Mancini, C; Bonomini, S; Ribatti, D; Pistoia, V; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola | |
| In vitro and In vivo evidences of osteocytes involvement in myeloma-induced osteolysis | 1-gen-2010 | Giuliani, Nicola; Storti, Paola; Abeltino, Manuela; Bolzoni, Marina; Ferretti, M; Lazzaretti, Mirca; Dalla Palma, B; Todoerti, K; Martella, E; Agnelli, L; Neri, A; Rizzoli, Vittorio; Palumbo, C. | |
| Increased osteocyte apoptosis in Multiple Myeloma patients: a potential role in bone remodeling alterations related to osteolytic bone lesions | 1-gen-2009 | Giuliani, Nicola; Ferretti, M; Abeltino, Manuela; Mancini, C; Martella, E; Dalla Palma, B; Bolzoni, Marina; Sgobba, V; Storti, Paola; Rizzoli, Vittorio; Palumbo, C. | |
| MEK-INHIBITORS/ARSENIC TRIOXIDE COMBINATION THERAPY AS A NOVEL TREATMENT OPTION FOR TYROSINE KINASE INHIBITORS-RESISTANT PH plus -LEUKEMIA | 1-gen-2020 | Mazzera, Laura; Abeltino, Manuela; Lombardi, Guerino; Cantoni, Anna Maria; Jottini, Stefano; Corradi, Attilio; Ricca, Micaela; Arienti, Davide; Peli, Angelo; Perris, Roberto; Bonati, Antonio; Lunghi, Paolo | |
| MEK-INHIBITORS/ARSENIC TRIOXIDE COMBINATION THERAPY AS A NOVEL TREATMENT OPTION FOR TYROSINE KINASE INHIBITORS-RESISTANT PH+-LEUKEMIA | 1-gen-2020 | Mazzera, L.; Abeltino, M.; Lombardi, G.; Cantoni, A. M.; Jottini, S.; Corradi, A.; Ricca, M.; Arienti, D.; Peli, A.; Perris, R.; Bonati, A.; Lunghi, P. | |
| MEK1/2 KINASES DISABLE THE TUMOR SUPPRESSOR FUNCTIONS OF NATIVE BCR AND ABL1 KINASES TO IMPAIR ANTICANCER DRUGS’ RESPONSIVENESS IN TKI-RESISTANT PHILADELPHIA POSITIVE LEUKEMIAS | 1-gen-2024 | Mazzera, L.; Abeltino, M.; Lombardi, G.; Cantoni, A. M.; Jottini, S.; Corradi, A.; Ricca, M.; Rossetti, E.; Armando, F.; Peli, A.; Ferrari, A.; Martinelli, G.; Scupoli, M. T.; Visco, C.; Bonifacio, M.; Ripamonti, A.; Gambacorti-Passerini, C.; Bonati, A.; Perris, R.; Lunghi, P. | |
| MEK1/2 regulate normal BCR and ABL1 tumor-suppressor functions to dictate ATO response in TKI-resistant Ph+ leukemia | 1-gen-2023 | Mazzera, Laura; Abeltino, Manuela; Lombardi, Guerino; Cantoni, Anna Maria; Jottini, Stefano; Corradi, Attilio; Ricca, Micaela; Rossetti, Elena; Armando, Federico; Peli, Angelo; Ferrari, Anna; Martinelli, Giovanni; Teresa Scupoli, Maria; Visco, Carlo; Bonifacio, Massimiliano; Ripamonti, Alessia; Gambacorti-Passerini, Carlo; Bonati, Antonio; Perris, Roberto; Lunghi, Paolo | |
| Myeloma cells inhibit the non-canonical wnt co-receptor ror2 in human mesenchymal/osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on mm-induced impairment of the osteogenic differentiation process | 1-gen-2009 | Bolzoni, Marina; Colla, S; Storti, Paola; Donofrio, Gaetano; Abeltino, Manuela; Sgobba, V; Bonomini, S; Rizzoli, Vittorio; Giuliani, Nicola | |
| Non canonical wnt signal pathway (Wnt5a/ror2) activation stimulates the osteogenic differentiation process of bone mesenchymal cells being a potential target in multiple myeloma bone disease | 1-gen-2010 | Bolzoni, Marina; Storti, Paola; Donofrio, Gaetano; Abeltino, Manuela; Colla, S; Bonomini, S; Rizzoli, Vittorio; Giuliani, Nicola | |
| Oxygen tension in the bone marrow (BM) of patients with malignant and indolent monoclonal gammopathy: role of hypoxia and hypoxia-inducible factor (HIF)-1{alpha} in the regulation of gene expression and pro-angiogenic profiles of CD138+ cells | 1-gen-2009 | Giuliani, Nicola; Colla, S; Storti, Paola; Sgobba, V; Todoerti, K; Donofrio, Gaetano; Bolzoni, Marina; Abeltino, Manuela; Lazzaretti, Mirca; Bonomini, S; Crugnola, M; Neri, A; Rizzoli, Vittorio | |
| The homeobox gene HOXB7 regulates the production of pro-angiogenic molecole by myeloma cells and it is a target in myeloma-induced angiogenesis | 1-gen-2010 | Storti, Paola; Donofrio, Gaetano; Bolzoni, Marina; Abeltino, Manuela; Colla, S; Airoldi, I; Todoerti, K; Agnelli, L; Lazzaretti, Mirca; Bonomini, S; Dalla Palma, B; Sammarelli, Gabriella; Ribatti, D; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola | |
| The IMID CC-4047 (Pomalidomide) inhibits myeloma-induced osteoclast formation | 1-gen-2010 | Abeltino, Manuela; Bolzoni, Marina; Storti, Paola; Bonomini, S; Pariyyarath, R; Rizzoli, Vittorio; Giuliani, Nicola | |
| The Immunomodulatory drugs Lenalidomide and Pomalidomide inhibit multiple myeloma-induced osteoclast formation and RANKL/OPG ratio in myeloma microenvironment targeting the expression of adhesion molecules | 1-gen-2010 | Bolzoni, Marina; Abeltino, Manuela; Storti, Paola; Bonomini, S; Agnelli, L; Todoerti, K; Neri, A; Rizzoli, Vittorio; Giuliani, Nicola | |
| The Pharmacological Blockade of Phosphodiesterase IV Potentiates the Anti-Tumor Effects of Arsenic Trioxide (ATO) in Acute Myelogenous Leukemia Cells through Multiple Signaling Pathways | 1-gen-2017 | Mazzera, L; Abeltino, M; Bonati, A; Lunghi, P |