Selective construction of complex molecular architectures through the activation of C-C π-bonds

In recent years, radical chemistry has undergone remarkable development through the advent of visible-light-driven processes. Within this context, my research focused on the generation and control of biradical species coming from the sensitization of allenamides, allowing the synthesis of interesting products of intermolecular dearomatization, β-lactams and strained heterocycles such as 2-azabicyclo[2.1.1]hexanes scaffolds, all having a high pharmaceutical relevance. Furthermore, I investigated the enantioselective reactivity of triene-carbamates catalyzed by chiral phosphoric acids (CPA), leading to the isolation of enantioenriched aldehydes and revealing a promising approach for asymmetric functionalization of complex substrates. Overall, this work introduces novel catalytic concepts based on unconventional non-covalent interactions, paving the way toward sustainable and efficient synthesis of highly three-dimensional molecular architectures.