CRISPR systems, beyond genome editing, can be repurposed for biosensing. This work develops strategies that link protein activity to CRISPR activation, engineer transcription factor–responsive circuits, and confine nucleases within DNA origami for multiplexed detection. Together, these approaches expand CRISPR’s analytical scope by integrating protein responsiveness, molecular logic, and spatial control.
Expanding CRISPR-Cas Systems for Protein-Responsive and Multiplexed Sensing Platforms / Capelli, L.. - (2026 Mar 27).
Expanding CRISPR-Cas Systems for Protein-Responsive and Multiplexed Sensing Platforms
CAPELLI, LUCA
2026-03-27
Abstract
CRISPR systems, beyond genome editing, can be repurposed for biosensing. This work develops strategies that link protein activity to CRISPR activation, engineer transcription factor–responsive circuits, and confine nucleases within DNA origami for multiplexed detection. Together, these approaches expand CRISPR’s analytical scope by integrating protein responsiveness, molecular logic, and spatial control.File in questo prodotto:
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