Transcription factors are regulatory proteins that can increase or decrease the transcription of a particular gene from deoxyribonucleic acid into the corresponding ribonucleic acid. They play a key role in embryonic development, the creation and maintenance of cell type- and tissue-specific patterns of protein synthesis and the response to cellular signaling pathways. Transcription factors are involved in a large number of human diseases such as congenital malformations, hereditary syndromes and a myriad of benignant and malignant neoplasms. Some transcription factors in addition to their regulation of homeostatic genes control the expression of many inflammatory genes and may, therefore, play a key role in the pathogenesis of a rapidly growing number of inflammatory/autoimmune diseases contributing to determine disease severity and response to treatment.

Transcription Factors / Caramori, Gaetano; Ruggeri, Paolo; Mumby, Sharon; Atzeni, Fabiola; Adcock., Ian M. - ELETTRONICO. - (2019), pp. 1-8. [10.1002/9780470015902.a0005278.pub3]

Transcription Factors

Gaetano Caramori;
2019-01-01

Abstract

Transcription factors are regulatory proteins that can increase or decrease the transcription of a particular gene from deoxyribonucleic acid into the corresponding ribonucleic acid. They play a key role in embryonic development, the creation and maintenance of cell type- and tissue-specific patterns of protein synthesis and the response to cellular signaling pathways. Transcription factors are involved in a large number of human diseases such as congenital malformations, hereditary syndromes and a myriad of benignant and malignant neoplasms. Some transcription factors in addition to their regulation of homeostatic genes control the expression of many inflammatory genes and may, therefore, play a key role in the pathogenesis of a rapidly growing number of inflammatory/autoimmune diseases contributing to determine disease severity and response to treatment.
2019
9780470015902
Transcription Factors / Caramori, Gaetano; Ruggeri, Paolo; Mumby, Sharon; Atzeni, Fabiola; Adcock., Ian M. - ELETTRONICO. - (2019), pp. 1-8. [10.1002/9780470015902.a0005278.pub3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2964247
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