As implied by the idiotypic network theory, the interaction between the functional epitope of a microbicidal molecule (X) and its specific cell-wall receptor (RX) on sensitive microorganisms may be imaged by the bond between the idiotype (Id) of a neutralizing monoclonal antibody (anti-X Ab) and its anti-idiotype (anti-Id) X-like Ab (anti-anti-X Ab). Consequently, anti-X Ab Id may mimic RX acting as a vaccine (idiotypic vaccination) for the elicitation of protective anti-Id Abs with antibiotic activity (antibiobodies).
Idiotypic antifungal vaccination: Immunoprotection by antiidiotypic antibiotic antibodies / Polonelli, Luciano; Magliani, Valter; Conti, Stefania. - STAMPA. - 1625:(2017), pp. 97-112. [10.1007/978-1-4939-7104-6_8]
Idiotypic antifungal vaccination: Immunoprotection by antiidiotypic antibiotic antibodies
POLONELLI, Luciano;MAGLIANI, Valter;CONTI, Stefania
2017-01-01
Abstract
As implied by the idiotypic network theory, the interaction between the functional epitope of a microbicidal molecule (X) and its specific cell-wall receptor (RX) on sensitive microorganisms may be imaged by the bond between the idiotype (Id) of a neutralizing monoclonal antibody (anti-X Ab) and its anti-idiotype (anti-Id) X-like Ab (anti-anti-X Ab). Consequently, anti-X Ab Id may mimic RX acting as a vaccine (idiotypic vaccination) for the elicitation of protective anti-Id Abs with antibiotic activity (antibiobodies).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
