Bioartificial endocrine organs comprise classical endocrine glands, and soft (parenchyma) and hard (mineralized) tissue organs involved in endocrine-metabolic regulation. These bioconstructs are one of the newest promises of regenerative medicine, but their bioengineering “on the laboratory bench” and thus, outside the living body (i.e. ex situ) remains a substantial challenge [1, 2]. Based on current concepts [3–5], bioartificial endocrine organs can be engineered ex situ using macroscopic, three-dimensional (3D) scaffolds that mimic the 3D architecture of the native, organ stromal support (here coined organomorphism) reproduced with either natural or synthetic biomaterials. Once pluripotent stem cells, tissue-committed progenitors, and differentiated primary cells are seeded and co-cultured with the organomorphic scaffold, their self-assembly is expected up to the formation of a 3D macroscopic, functional and immuno-tolerant organ, replicating the native one. However, 3D systems exhibiting appropriate flow and trophic performance (bioreactor) are required to maximize homing, survival, growth, and differentiation/transdifferentiation of seeded elements [3, 6, 7]. Embryonic stem cells (ESCs) and induced pluripotent stem cells are also raising hopes as valuable sources to bioengineer human bioartificial viscera [8, 9]; thus, in the near future they may become another option to reconstruct ex situ bioartificial endocrine organs.

Bioartificial endocrine organs: at the cutting edge of translational research in endocrinology / Toni, Roberto; Bassi, Elena; Nicoletta, Zini; Zamparelli, Alessandra; Barbaro, Fulvio; Dallatana, Davide; Salvatore, Mosca; Lippi, Giuseppe; Giulia, Spaletta; Elena, Bassoli; Lucia, Denti; Andrea, Gatto; Annapaola, Parrilli; Milena, Fini; Roberto, Giardino; Monica, Sandri; Simone, Sprio; Anna, Tampieri. - (2016), pp. 357-387.

Bioartificial endocrine organs: at the cutting edge of translational research in endocrinology

TONI, Roberto;BASSI, Elena;ZAMPARELLI, Alessandra;BARBARO, Fulvio;DALLATANA, Davide;LIPPI, Giuseppe;
2016-01-01

Abstract

Bioartificial endocrine organs comprise classical endocrine glands, and soft (parenchyma) and hard (mineralized) tissue organs involved in endocrine-metabolic regulation. These bioconstructs are one of the newest promises of regenerative medicine, but their bioengineering “on the laboratory bench” and thus, outside the living body (i.e. ex situ) remains a substantial challenge [1, 2]. Based on current concepts [3–5], bioartificial endocrine organs can be engineered ex situ using macroscopic, three-dimensional (3D) scaffolds that mimic the 3D architecture of the native, organ stromal support (here coined organomorphism) reproduced with either natural or synthetic biomaterials. Once pluripotent stem cells, tissue-committed progenitors, and differentiated primary cells are seeded and co-cultured with the organomorphic scaffold, their self-assembly is expected up to the formation of a 3D macroscopic, functional and immuno-tolerant organ, replicating the native one. However, 3D systems exhibiting appropriate flow and trophic performance (bioreactor) are required to maximize homing, survival, growth, and differentiation/transdifferentiation of seeded elements [3, 6, 7]. Embryonic stem cells (ESCs) and induced pluripotent stem cells are also raising hopes as valuable sources to bioengineer human bioartificial viscera [8, 9]; thus, in the near future they may become another option to reconstruct ex situ bioartificial endocrine organs.
2016
978-981-4669-14-6
Bioartificial endocrine organs: at the cutting edge of translational research in endocrinology / Toni, Roberto; Bassi, Elena; Nicoletta, Zini; Zamparelli, Alessandra; Barbaro, Fulvio; Dallatana, Davide; Salvatore, Mosca; Lippi, Giuseppe; Giulia, Spaletta; Elena, Bassoli; Lucia, Denti; Andrea, Gatto; Annapaola, Parrilli; Milena, Fini; Roberto, Giardino; Monica, Sandri; Simone, Sprio; Anna, Tampieri. - (2016), pp. 357-387.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2748100
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