Recent findings on brain and neuroendocrine dysfunction associated with styrene exposure are reviewed here. Mechanistic aspects of solvent neurotoxicity and markers potentially applicable to human biomonitoring are also discussed with the aim of providing an overview of current research findings and research needs in this area. reactive carbonylic groups are common to a number of hydrocarbons biotransformed into their alpha-ketoacids or aldehydes. Such reactive metabolites condense with dopamine to form tetrahydroisoquinolines (TIQ), some of which may cross the blood-brain barrier and show multiple interferences with catecholamine synthesis, inhibiting tyrosine hydroxylase and monoamine oxidases B (MAO-B) and enhancing the activity of dopamine-beta-hydroxylase (DBH). TIQ are good candidates to explain the selective vulnerability of dopaminercic systems to styrene exposure. Despite a stimulating mechanistic basis, the measurement of TIQ in biological media cannot be proposed yet as a marker of effective dose, because of the great analytical difficulties. On the contrary, the activity of MAO-B in platelets and of DBH in serum can be envisaged as suitable biomarkers to monitor styrene-exposed groups, whereas caution must be exercised in their application at the individual level.

Mechanisms and markers of styrene-induced behavioural and neuroendocrine changes / Mutti, Antonio; R., Alinovi; A., Bacchini; Bergamaschi, Enrico; C., Biagini; A., Smargiassi; S., Cavazzini; I., Franchini. - (1993), pp. 126-137.

Mechanisms and markers of styrene-induced behavioural and neuroendocrine changes.

MUTTI, Antonio;BERGAMASCHI, Enrico;
1993-01-01

Abstract

Recent findings on brain and neuroendocrine dysfunction associated with styrene exposure are reviewed here. Mechanistic aspects of solvent neurotoxicity and markers potentially applicable to human biomonitoring are also discussed with the aim of providing an overview of current research findings and research needs in this area. reactive carbonylic groups are common to a number of hydrocarbons biotransformed into their alpha-ketoacids or aldehydes. Such reactive metabolites condense with dopamine to form tetrahydroisoquinolines (TIQ), some of which may cross the blood-brain barrier and show multiple interferences with catecholamine synthesis, inhibiting tyrosine hydroxylase and monoamine oxidases B (MAO-B) and enhancing the activity of dopamine-beta-hydroxylase (DBH). TIQ are good candidates to explain the selective vulnerability of dopaminercic systems to styrene exposure. Despite a stimulating mechanistic basis, the measurement of TIQ in biological media cannot be proposed yet as a marker of effective dose, because of the great analytical difficulties. On the contrary, the activity of MAO-B in platelets and of DBH in serum can be envisaged as suitable biomarkers to monitor styrene-exposed groups, whereas caution must be exercised in their application at the individual level.
1993
8886281005
Mechanisms and markers of styrene-induced behavioural and neuroendocrine changes / Mutti, Antonio; R., Alinovi; A., Bacchini; Bergamaschi, Enrico; C., Biagini; A., Smargiassi; S., Cavazzini; I., Franchini. - (1993), pp. 126-137.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2439906
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