Sfoglia per Autore
Advances in the set-up of a fluorescence- anisotropy assay for the search of novel inhibitors of the tead-4 complexes
2019-01-01 Romito, Filippo; Tagliazucchi, Lorenzo; Pozzi, Cecilia; Mangani, Stefano; Lopresti, Ludovica; Ponterini, Glauco; Paola Costi, Maria
Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment
2021-01-01 Lopresti, Ludovica; Pozzi, Cecilia; Tagliazucchi, L; D’Arca, D; Marverti, G; Costi, Mp; Mangani, Stefano
UHPLC-MS/MS screening of the hTEAD surface for the identification of novel allosteric inhibitors with anticancer activity
2021-01-01 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Mangani, Stefano; Abdel Latif, Andrea; Ponterini, Glauco; Venturelli, Alberto; Paola Costi, Maria
Targeting of the Cysteines Surface domain of the Transcriptional Enhancer Associate Domain (TEAD) for anticancer drug discovery
2021-01-01 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Mangani, Stefano; Lopresti, Ludovica; Pozzi, Cecilia; Ponterini, Glauco; Venturelli, Alberto; Paola Costi, Maria
Proteomic contribution to the omic path for the identification of novel drugs overcoming resistance in Leishmaniasis
2021-01-01 Tagliazucchi, Lorenzo; Fiorini, Greta; Perea-Martínez, Ana; García- Hernández, Raquel; Ignacio Manzano, José; Paola Costi, Maria; Gamarro, Francisco
Coupling a microwave-assisted process with HPLC-ELSD for the extraction, purification and analysis of bioactive policosanols from beeswax
2021-01-01 Venturelli, Alberto; Brighenti, Virginia; Tagliazucchi, Lorenzo; Paola Costi, Maria; Pellati, Federica
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth
2021-01-01 Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Paola Costi, Maria
Development of guanidino-containing benzimidazoles as novel folate enzymes inhibitors for the treatment of Human African Trypanosomiasis
2021-01-01 Rizzo, Marco; Francesconi, Valeria; Cichero, Elena; Schenone, Silvia; Tagliazucchi, Lorenzo; Cordeiro Da Silva, Anabela; Paola Costi, Maria; Tonelli, Michele
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme
2021-01-01 Tagliazucchi, Lorenzo; Marverti, Gaetano; D’Arca, Domenico; Ponterini, Glauco; Paola Costi, Maria
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase
2021-01-01 Tassone, Giusy; Landi, Giacomo; Linciano, Pasquale; Francesconi, Valeria; Tonelli, Michele; Tagliazucchi, Lorenzo; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases
2021-01-01 Santucci, Matteo; Luciani, Rosaria; Gianquinto, Eleonora; Pozzi, Cecilia; Pisa, Flavio Di; Dello Iacono, Lucia; Landi, Giacomo; Tagliazucchi, Lorenzo; Mangani, Stefano; Spyrakis, Francesca; Costi, Maria Paola
Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting
2021-01-01 Marverti, Gaetano; Marraccini, Chiara; Martello, Andrea; D'Arca, Domenico; Pacifico, Salvatore; Guerrini, Remo; Spyrakis, Francesca; Gozzi, Gaia; Lauriola, Angela; Santucci, Matteo; Cannazza, Giuseppe; Tagliazucchi, Lorenzo; Cazzato, Addolorata Stefania; Losi, Lorena; Ferrari, Stefania; Ponterini, Glauco; Costi, Maria P.
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations
2021-01-01 Pozzi, Cecilia; Santucci, Matteo; Marverti, Gaetano; D'Arca, Domenico; Tagliazucchi, Lorenzo; Ferrari, Stefania; Gozzi, Gaia; Losi, Lorena; Tassone, Giusy; Mangani, Stefano; Ponterini, Glauco; Costi, Maria Paola
LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients
2022-01-01 Tagliazucchi, Lorenzo; Gaetana Moschella, Maria; D'Addese, Gianluca; Califano, Daniela; Arenare, Laura; Mezzanzanico, Delia; Chinello, Clizia; Magni, Fulvio; Villani, Marco; Losi, Lorena; Marverti, Gaetano; D’Arca, Domenico; Chiodini, Paolo; Pignata, Sandro; Paola Costi, Maria
Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption
2022-01-01 Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Paola Costi, Maria
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties
2022-01-01 Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Gaetana Moschella, Maria; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D’Arca, Domenico; Ponterini, Glauco; Paola Costi, Maria
Discovery of guanidino-containing benzimidazoles as novel antifolates for Trypanosomiasis
2022-01-01 Francesconi, Valeria; Rizzo, Marco; Tagliazucchi, Lorenzo; Pozzi, Cecilia; Cordeiro-da-Silva, Anabela; Venuti, Federica; Konchie, Claude; Paola Costi, Maria; Michele, Tonelli
Expression, purification, and characterization of Transcriptional Enhancer Associated Domain (hTEAD4), a promising target for anticancer agents
2022-01-01 Tagliazucchi, L; Rossi, Marianna; Pozzi, Cecilia; Lopresti, Ludovica; Aiello, D; Venturelli, A; Ponterini, G; Costi, Mp
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase
2022-01-01 Aiello, Daniele; Ascione, Cristian; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Cassanelli, Valentina; Ponterini, Glauco; D’Arca, Domenico; Marverti, Gaetano; Gaetana Moschella, Maria; Falchi, Federico; Venturelli, Alberto; Paola Costi, Maria
LC-MS/MS Helps Characterizing THP-1 Cells Proteome After Infection with Drug Resistant Leishmania Strains
2022-01-01 Tagliazucchi, Lorenzo; Perea-Martinez, Ana; Fiorini, Greta; Ignacio Manzano, José; García-Hernández, Raquel; Genovese, Filippo; Pinetti, Diego; Gamarro, Francisco; Paola Costi, Maria
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Advances in the set-up of a fluorescence- anisotropy assay for the search of novel inhibitors of the tead-4 complexes | 1-gen-2019 | Romito, Filippo; Tagliazucchi, Lorenzo; Pozzi, Cecilia; Mangani, Stefano; Lopresti, Ludovica; Ponterini, Glauco; Paola Costi, Maria | |
| Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment | 1-gen-2021 | Lopresti, Ludovica; Pozzi, Cecilia; Tagliazucchi, L; D’Arca, D; Marverti, G; Costi, Mp; Mangani, Stefano | |
| UHPLC-MS/MS screening of the hTEAD surface for the identification of novel allosteric inhibitors with anticancer activity | 1-gen-2021 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Mangani, Stefano; Abdel Latif, Andrea; Ponterini, Glauco; Venturelli, Alberto; Paola Costi, Maria | |
| Targeting of the Cysteines Surface domain of the Transcriptional Enhancer Associate Domain (TEAD) for anticancer drug discovery | 1-gen-2021 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Mangani, Stefano; Lopresti, Ludovica; Pozzi, Cecilia; Ponterini, Glauco; Venturelli, Alberto; Paola Costi, Maria | |
| Proteomic contribution to the omic path for the identification of novel drugs overcoming resistance in Leishmaniasis | 1-gen-2021 | Tagliazucchi, Lorenzo; Fiorini, Greta; Perea-Martínez, Ana; García- Hernández, Raquel; Ignacio Manzano, José; Paola Costi, Maria; Gamarro, Francisco | |
| Coupling a microwave-assisted process with HPLC-ELSD for the extraction, purification and analysis of bioactive policosanols from beeswax | 1-gen-2021 | Venturelli, Alberto; Brighenti, Virginia; Tagliazucchi, Lorenzo; Paola Costi, Maria; Pellati, Federica | |
| Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth | 1-gen-2021 | Tagliazucchi, Lorenzo; Malpezzi, Giulia; Pozzi, Cecilia; Lopresti, Ludovica; Venturelli, Alberto; D'Arca, Domenico; Marverti, Gaetano; Cecconi, Ciro; Ponterini, Glauco; Paola Costi, Maria | |
| Development of guanidino-containing benzimidazoles as novel folate enzymes inhibitors for the treatment of Human African Trypanosomiasis | 1-gen-2021 | Rizzo, Marco; Francesconi, Valeria; Cichero, Elena; Schenone, Silvia; Tagliazucchi, Lorenzo; Cordeiro Da Silva, Anabela; Paola Costi, Maria; Tonelli, Michele | |
| Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme | 1-gen-2021 | Tagliazucchi, Lorenzo; Marverti, Gaetano; D’Arca, Domenico; Ponterini, Glauco; Paola Costi, Maria | |
| Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase | 1-gen-2021 | Tassone, Giusy; Landi, Giacomo; Linciano, Pasquale; Francesconi, Valeria; Tonelli, Michele; Tagliazucchi, Lorenzo; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia | |
| Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases | 1-gen-2021 | Santucci, Matteo; Luciani, Rosaria; Gianquinto, Eleonora; Pozzi, Cecilia; Pisa, Flavio Di; Dello Iacono, Lucia; Landi, Giacomo; Tagliazucchi, Lorenzo; Mangani, Stefano; Spyrakis, Francesca; Costi, Maria Paola | |
| Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting | 1-gen-2021 | Marverti, Gaetano; Marraccini, Chiara; Martello, Andrea; D'Arca, Domenico; Pacifico, Salvatore; Guerrini, Remo; Spyrakis, Francesca; Gozzi, Gaia; Lauriola, Angela; Santucci, Matteo; Cannazza, Giuseppe; Tagliazucchi, Lorenzo; Cazzato, Addolorata Stefania; Losi, Lorena; Ferrari, Stefania; Ponterini, Glauco; Costi, Maria P. | |
| Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations | 1-gen-2021 | Pozzi, Cecilia; Santucci, Matteo; Marverti, Gaetano; D'Arca, Domenico; Tagliazucchi, Lorenzo; Ferrari, Stefania; Gozzi, Gaia; Losi, Lorena; Tassone, Giusy; Mangani, Stefano; Ponterini, Glauco; Costi, Maria Paola | |
| LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients | 1-gen-2022 | Tagliazucchi, Lorenzo; Gaetana Moschella, Maria; D'Addese, Gianluca; Califano, Daniela; Arenare, Laura; Mezzanzanico, Delia; Chinello, Clizia; Magni, Fulvio; Villani, Marco; Losi, Lorena; Marverti, Gaetano; D’Arca, Domenico; Chiodini, Paolo; Pignata, Sandro; Paola Costi, Maria | |
| Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption | 1-gen-2022 | Tagliazucchi, Lorenzo; Rossi, Marianna; Malpezzi, Giulia; Zappaterra, Dana; Aiello, Daniele; Pozzi, Cecilia; Pacifico, Salvatore; Guerrini, Remo; Venturelli, Alberto; Ponterini, Glauco; Paola Costi, Maria | |
| A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties | 1-gen-2022 | Tagliazucchi, Lorenzo; Venturelli, Alberto; Malpezzi, Giulia; Gaetana Moschella, Maria; Aiello, Daniele; Lopresti, Ludovica; Pozzi, Cecilia; Marverti, Gaetano; D’Arca, Domenico; Ponterini, Glauco; Paola Costi, Maria | |
| Discovery of guanidino-containing benzimidazoles as novel antifolates for Trypanosomiasis | 1-gen-2022 | Francesconi, Valeria; Rizzo, Marco; Tagliazucchi, Lorenzo; Pozzi, Cecilia; Cordeiro-da-Silva, Anabela; Venuti, Federica; Konchie, Claude; Paola Costi, Maria; Michele, Tonelli | |
| Expression, purification, and characterization of Transcriptional Enhancer Associated Domain (hTEAD4), a promising target for anticancer agents | 1-gen-2022 | Tagliazucchi, L; Rossi, Marianna; Pozzi, Cecilia; Lopresti, Ludovica; Aiello, D; Venturelli, A; Ponterini, G; Costi, Mp | |
| Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase | 1-gen-2022 | Aiello, Daniele; Ascione, Cristian; Tagliazucchi, Lorenzo; Malpezzi, Giulia; Cassanelli, Valentina; Ponterini, Glauco; D’Arca, Domenico; Marverti, Gaetano; Gaetana Moschella, Maria; Falchi, Federico; Venturelli, Alberto; Paola Costi, Maria | |
| LC-MS/MS Helps Characterizing THP-1 Cells Proteome After Infection with Drug Resistant Leishmania Strains | 1-gen-2022 | Tagliazucchi, Lorenzo; Perea-Martinez, Ana; Fiorini, Greta; Ignacio Manzano, José; García-Hernández, Raquel; Genovese, Filippo; Pinetti, Diego; Gamarro, Francisco; Paola Costi, Maria |
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