Sfoglia per Autore
Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity.
2015-01-01 Tognolini, Massimiliano; Giorgio, Carmine; Festuccia, C; Rusnati, M; Chiodelli, P; Incerti, Matteo; Pala, Daniele; Callegari, Donatella; Bertoni, Simona; Castelli, Riccardo; Lodola, Alessio; Barocelli, Elisabetta
In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth
2015-01-01 Giorgio, Carmine; Castelli, Riccardo; Hassan Mohamed, I.; Incerti, Matteo; Vacondio, Federica; Bertoni, Simona; Festuccia, C.; Pala, Daniele; Lodola, Alessio; Barocelli, Elisabetta; Tognolini, Massimiliano
Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction
2015-01-01 Tognolini, Massimiliano; Giorgio, Carmine; Incerti, Matteo; Castelli, Riccardo; Festuccia, C.; Rusnati, M.; Vacondio, Federica; Russo, Simonetta; Pala, Daniele; Callegari, Donatella; Mor, Marco; Bertoni, Simona; Ballabeni, Vigilio; Lodola, Alessio; Barocelli, Elisabetta
Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats
2015-01-01 Vacondio, Federica; Bassi, Michele; Silva, Claudia; Castelli, Riccardo; Carmi, Caterina; Scalvini, Laura; Lodola, Alessio; Vivo, Valentina; Flammini, Lisa; Barocelli, Elisabetta; Mor, Marco; Rivara, Silvia
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging
2015-01-01 Matusiak, Nathalie; Castelli, Riccardo; Tuin, Adriaan W.; Overkleeft, Herman S.; Wisastra, Rosalina; Dekker, Frank J.; Prély, Laurette M.; Bischoff, Rainer P. M.; Van Waarde, Aren; Dierckx, Rudi A. J. O.; Elsinga, Philip H.
Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014)
2015-01-01 Lodola, Alessio; Castelli, Riccardo; Mor, Marco; Rivara, Silvia
MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation
2015-01-01 Matusiak, Nathalie; van Waarde, Aren; Rozeveld, Dennie; van Oosterhout, Antoon J. M.; Heijink, Irene H.; Castelli, Riccardo; Overkleeft, Hermen S.; Bischoff, Rainer; Dierckx, Rudi A. J. O.; Elsinga, Philip H.
Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system
2015-01-01 Castelli, Riccardo; Tognolini, Massimiliano; Vacondio, Federica; Incerti, Matteo; Pala, Daniele; Callegari, Donatella; Bertoni, Simona; Giorgio, Carmine; Hassan Mohamed, I; Zanotti, Ilaria; Bugatti, A; Rusnati, M; Festuccia, C; Rivara, Silvia; Barocelli, Elisabetta; Mor, Marco; Lodola, Alessio
Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors
2016-01-01 Castelli, Riccardo; Giacomini, Arianna; Anselmi, Mattia; Bozza, Nicole; Vacondio, Federica; Rivara, Silvia; Matarazzo, Sara; Presta, Marco; Mor, Marco; Ronca, Roberto
Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence.
2017-01-01 Giorgio, Carmine; Festuccia, Claudio; Gravina, Giovanni L.; Castelli, Riccardo; Rusnati, Marco; Chiodelli, Paola; Vacondio, Federica; Pala, Daniele; Callegari, Donatella; Barocelli, Elisabetta; Lodola, Alessio; Tognolini, Massimiliano
Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo
2017-01-01 Cretella, D; Fumarola, C; la Monica, S; Alfieri, R; Bozza, N; Castelli, R; Mor, M; Petronini, Pg; Cavazzoni, A.
Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history
2017-01-01 Tognolini, Massimiliano; Claudio, Festuccia; Gianluca, Gravina; Castelli, Riccardo; Incerti, Matteo; Vacondio, Federica; Callegari, Donatella; Simonetta, Russo; Barocelli, Elisabetta; Marco, Rusnati; Paola, Chiodelli; Lodola, Alessio; Giorgio, Carmine
Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor
2017-01-01 Incerti, Matteo; Russo, Simonetta; Callegari, Donatella; Pala, Daniele; Giorgio, Carmine; Zanotti, Ilaria; Barocelli, Elisabetta; Vicini, Paola; Vacondio, Federica; Rivara, Silvia; Castelli, Riccardo; Tognolini, Massimiliano; Lodola, Alessio
Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury
2017-01-01 Vivo, Valentina; Zini, Irene; Cantoni, Anna Maria; Grandi, Andrea; Tognolini, Massimiliano; Castelli, Riccardo; Ballabeni, Vigilio; Bertoni, Simona; Barocelli, Elisabetta
UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice
2018-01-01 Festuccia, Claudio; Gravina, Giovanni Luca; Giorgio, Carmine; Mancini, Andrea; Pellegrini, Cristina; Colapietro, Alessandro; Monache, Simona Delle; Maturo, Maria Giovanna; Sferra, Roberta; Chiodelli, Paola; Rusnati, Marco; Cantoni, Anna maria; Castelli, Riccardo; Vacondio, Federica; Lodola, Alessio; Tognolini, Massimiliano
Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD
2019-01-01 Grandi, A.; Zini, I.; Palese, Simone; Giorgio, C.; Tognolini, M.; Marchesani, F.; Bruno, S.; Flammini, L.; Cantoni, A. M.; Castelli, R.; Lodola, A.; Fusari, A.; Barocelli, E.; Bertoni, S.
Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines.
2019-01-01 Fumarola, C; Bozza, N; Castelli, R; Ferlenghi, F; Marseglia, Giuseppe; Lodola, A; Bonelli, M; La Monica, S; Cretella, D; Alfieri, R; Minari, R; Galetti, M; Tiseo, M; Ardizzoni, A; Mor, M; Petronini, Pg.
Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR
2019-01-01 Castelli, R; Bozza, N; Cavazzoni, A; Bonelli, M; Vacondio, F; Ferlenghi, F; Callegari, D; Silva, C; Rivara, S; Lodola, A; Digiacomo, G; Fumarola, C; Alfieri, R; Petronini, Pg; Mor, M.
Fibroblast growth factor receptor inhibitors: patent review (2015–2019)
2019-01-01 Marseglia, Giuseppe; Lodola, Alessio; Mor, Marco; Castelli, Riccardo
Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties
2020-01-01 Incerti, M.; Russo, S.; Corrado, M.; Giorgio, C.; Ballabeni, V.; Chiodelli, P.; Rusnati, M.; Scalvini, L.; Callegari, D.; Castelli, R.; Vacondio, F.; Ferlenghi, F.; Tognolini, M.; Lodola, A.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Development of an orally bioavailable small molecule targeting Eph-ephrin system: in vitro and in vivo anticancer activity. | 1-gen-2015 | Tognolini, Massimiliano; Giorgio, Carmine; Festuccia, C; Rusnati, M; Chiodelli, P; Incerti, Matteo; Pala, Daniele; Callegari, Donatella; Bertoni, Simona; Castelli, Riccardo; Lodola, Alessio; Barocelli, Elisabetta | |
| In vitro and in vivo efficacy of an orally bioavailable antagonist of Eph-ephrin system in tumor angiogenesis and growth | 1-gen-2015 | Giorgio, Carmine; Castelli, Riccardo; Hassan Mohamed, I.; Incerti, Matteo; Vacondio, Federica; Bertoni, Simona; Festuccia, C.; Pala, Daniele; Lodola, Alessio; Barocelli, Elisabetta; Tognolini, Massimiliano | |
| Multiple approaches for the discovery and development of small molecules targeting Eph-ephrin protein-protein interaction | 1-gen-2015 | Tognolini, Massimiliano; Giorgio, Carmine; Incerti, Matteo; Castelli, Riccardo; Festuccia, C.; Rusnati, M.; Vacondio, Federica; Russo, Simonetta; Pala, Daniele; Callegari, Donatella; Mor, Marco; Bertoni, Simona; Ballabeni, Vigilio; Lodola, Alessio; Barocelli, Elisabetta | |
| Amino acid derivatives as palmitoylethanolamide prodrugs: Synthesis, in vitro metabolism and in vivo plasma profile in rats | 1-gen-2015 | Vacondio, Federica; Bassi, Michele; Silva, Claudia; Castelli, Riccardo; Carmi, Caterina; Scalvini, Laura; Lodola, Alessio; Vivo, Valentina; Flammini, Lisa; Barocelli, Elisabetta; Mor, Marco; Rivara, Silvia | |
| A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [18F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging | 1-gen-2015 | Matusiak, Nathalie; Castelli, Riccardo; Tuin, Adriaan W.; Overkleeft, Herman S.; Wisastra, Rosalina; Dekker, Frank J.; Prély, Laurette M.; Bischoff, Rainer P. M.; Van Waarde, Aren; Dierckx, Rudi A. J. O.; Elsinga, Philip H. | |
| Fatty acid amide hydrolase inhibitors: a patent review (2009 - 2014) | 1-gen-2015 | Lodola, Alessio; Castelli, Riccardo; Mor, Marco; Rivara, Silvia | |
| MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [18F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation | 1-gen-2015 | Matusiak, Nathalie; van Waarde, Aren; Rozeveld, Dennie; van Oosterhout, Antoon J. M.; Heijink, Irene H.; Castelli, Riccardo; Overkleeft, Hermen S.; Bischoff, Rainer; Dierckx, Rudi A. J. O.; Elsinga, Philip H. | |
| Δ5-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system | 1-gen-2015 | Castelli, Riccardo; Tognolini, Massimiliano; Vacondio, Federica; Incerti, Matteo; Pala, Daniele; Callegari, Donatella; Bertoni, Simona; Giorgio, Carmine; Hassan Mohamed, I; Zanotti, Ilaria; Bugatti, A; Rusnati, M; Festuccia, C; Rivara, Silvia; Barocelli, Elisabetta; Mor, Marco; Lodola, Alessio | |
| Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors | 1-gen-2016 | Castelli, Riccardo; Giacomini, Arianna; Anselmi, Mattia; Bozza, Nicole; Vacondio, Federica; Rivara, Silvia; Matarazzo, Sara; Presta, Marco; Mor, Marco; Ronca, Roberto | |
| Eph-ephrin antagonism in tumor angiogenesis and growth: UniPR1331 preclinical evidence. | 1-gen-2017 | Giorgio, Carmine; Festuccia, Claudio; Gravina, Giovanni L.; Castelli, Riccardo; Rusnati, Marco; Chiodelli, Paola; Vacondio, Federica; Pala, Daniele; Callegari, Donatella; Barocelli, Elisabetta; Lodola, Alessio; Tognolini, Massimiliano | |
| Targeting FGFR1 pathway in non small cell lung cancer both in vitro and in vivo | 1-gen-2017 | Cretella, D; Fumarola, C; la Monica, S; Alfieri, R; Bozza, N; Castelli, R; Mor, M; Petronini, Pg; Cavazzoni, A. | |
| Discovery and development of small molecules targeting Eph-ephrin system in glioblastoma: an academic history | 1-gen-2017 | Tognolini, Massimiliano; Claudio, Festuccia; Gianluca, Gravina; Castelli, Riccardo; Incerti, Matteo; Vacondio, Federica; Callegari, Donatella; Simonetta, Russo; Barocelli, Elisabetta; Marco, Rusnati; Paola, Chiodelli; Lodola, Alessio; Giorgio, Carmine | |
| Metadynamics for perspective drug design: Computationally driven synthesis of new protein-protein interaction inhibitors targeting the EphA2 receptor | 1-gen-2017 | Incerti, Matteo; Russo, Simonetta; Callegari, Donatella; Pala, Daniele; Giorgio, Carmine; Zanotti, Ilaria; Barocelli, Elisabetta; Vicini, Paola; Vacondio, Federica; Rivara, Silvia; Castelli, Riccardo; Tognolini, Massimiliano; Lodola, Alessio | |
| Protection by the EPH-EPHRIN System Against Mesenteric Ischemia-Reperfusion Injury | 1-gen-2017 | Vivo, Valentina; Zini, Irene; Cantoni, Anna Maria; Grandi, Andrea; Tognolini, Massimiliano; Castelli, Riccardo; Ballabeni, Vigilio; Bertoni, Simona; Barocelli, Elisabetta | |
| UniPR1331, a small molecule targeting Eph/ephrin interaction, prolongs survival in glioblastoma and potentiates the effect of antiangiogenic therapy in mice | 1-gen-2018 | Festuccia, Claudio; Gravina, Giovanni Luca; Giorgio, Carmine; Mancini, Andrea; Pellegrini, Cristina; Colapietro, Alessandro; Monache, Simona Delle; Maturo, Maria Giovanna; Sferra, Roberta; Chiodelli, Paola; Rusnati, Marco; Cantoni, Anna maria; Castelli, Riccardo; Vacondio, Federica; Lodola, Alessio; Tognolini, Massimiliano | |
| Targeting the Eph/ephrin system as anti-inflammatory strategy in IBD | 1-gen-2019 | Grandi, A.; Zini, I.; Palese, Simone; Giorgio, C.; Tognolini, M.; Marchesani, F.; Bruno, S.; Flammini, L.; Cantoni, A. M.; Castelli, R.; Lodola, A.; Fusari, A.; Barocelli, E.; Bertoni, S. | |
| Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines. | 1-gen-2019 | Fumarola, C; Bozza, N; Castelli, R; Ferlenghi, F; Marseglia, Giuseppe; Lodola, A; Bonelli, M; La Monica, S; Cretella, D; Alfieri, R; Minari, R; Galetti, M; Tiseo, M; Ardizzoni, A; Mor, M; Petronini, Pg. | |
| Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR | 1-gen-2019 | Castelli, R; Bozza, N; Cavazzoni, A; Bonelli, M; Vacondio, F; Ferlenghi, F; Callegari, D; Silva, C; Rivara, S; Lodola, A; Digiacomo, G; Fumarola, C; Alfieri, R; Petronini, Pg; Mor, M. | |
| Fibroblast growth factor receptor inhibitors: patent review (2015–2019) | 1-gen-2019 | Marseglia, Giuseppe; Lodola, Alessio; Mor, Marco; Castelli, Riccardo | |
| Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties | 1-gen-2020 | Incerti, M.; Russo, S.; Corrado, M.; Giorgio, C.; Ballabeni, V.; Chiodelli, P.; Rusnati, M.; Scalvini, L.; Callegari, D.; Castelli, R.; Vacondio, F.; Ferlenghi, F.; Tognolini, M.; Lodola, A. |
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