Evaluation of a custom-made, titratable MAD (ORTHOAPNEA NOA®) for treatment of OSAS

Aim: The purpose of this study is to determine the effectiveness of ORTHOAPNEA NOA® MAD in the treatment of OSAS patients. Noa ® is a two-piece MAD, the first worldwide one customized according to the mandibular kinematic of each patient. Methods: The study is carried out on a sample recruited from the Department of Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Section of Dentistry of Pavia. The sample meets the following inclusion criteria: AHI>5, age between 18 and 75 years old, initial PSG supplied. PSG is repeated both at the baseline (T0) and 3 months after the start of therapy with NOA® (T1). Sleep parameters, such as AHI, supine AHI, ODI, SpO2<90% time, mean desaturation (%), are analyzed and compared between T0 and T1. Results: The evaluation of the effectiveness of the NOA device® is based on a sample of 7 patients, 3 males and 4 females (mean age 57,4±10,72). T0 indexes were AHI 19,4±8,74, supine AHI 34.58±14.46, ODI 13,25±9,87, SpO2<90% time 55.2±93.64 minutes, mean desaturation 92,74±2,23. This sample includes 4 patients with mild OSAS (5<AHI<15), one with moderate OSAS (15<AHI<30) and 2 with severe OSAS (AHI>30). After treatment with NOA®, a relevant decrease of AHI (8.5±1,55), supine AHI (6,95±0,77), ODI (10,05±0,9) and SpO2<90% (0,35±0,49min) was observed. Conclusion: MAD NOA® could be an effective alternative in the treatment of OSAS; the device has obtained significant results with the improvement of the PSG parameters.