Background: Non-invasive methods are advisable for the detection of Helicobacter pylori-related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-H. pylori antibodies (IgG-Hp) have been proposed as a 'serological gastric biopsy'. Aim: To assess H. pylori infection and to evaluate gastric mucosa status in a pediatric population by means of serological parameters such as sPGI, sPGII, G-17 and IgG-Hp. Methods: 45 consecutively children evaluated for upper gastrointestinal symptoms were analyzed. All children were submitted to upper gastrointestinal endoscopy with biopsies. Serum samples were analyzed for IgG-Hp, sPGII, sPGI and G-17 (Biohit, Helsinki, Finland). Results: 18 children had H. pylori-related mild or moderate non-atrophic chronic gastritis. They presented significantly higher mean levels of sPGII and of IgG-Hp than negative ones, eitherunder or up to 10 years. sPGI showed significantly increased levels in H. pylori-positive patients only over 10 years. G-17 levels were not different between H. pylori-positive and -negative ones. The best cut-offs of IgG-Hp, sPGII and of product IgG-Hp·sPGII, to identify H. pylori infection, were 30 IU/l, 9 μg/l, and 241 IU/l·μg/l, respectively. The product IgG-Hp·sPGII identified H. pylori infection with a 100% sensitivity, 92% specificity, 90% positive predictive value and 100% negative predictive value. IgG-Hp and IgG-Hp showed a correlation (r = 0.94; p < 0.001). Conclusions: Combined analysis of sPGII and IgG-Hp antibody levels could be recommended as a non-invasive panel for the assessment of H. pylori-related histological alterations of gastric mucosa in childhood. Copyright © 2007 S. Karger AG.

Usefulness of a serological panel test in the assessment of gastritis in symptomatic children / De Angelis, G. L.; Cavallaro, L. G.; Maffini, V.; Moussa, A. M.; Fornaroli, F.; Liatopoulou, S.; Bizzarri, B.; Merli, R.; Comparato, G.; Caruana, P.; Cavestro, G. M.; Franze, A.; Di Mario, F.. - In: DIGESTIVE DISEASES. - ISSN 0257-2753. - 25:3(2007), pp. 206-213. [10.1159/000103886]

Usefulness of a serological panel test in the assessment of gastritis in symptomatic children

De Angelis G. L.;Maffini V.;Fornaroli F.;Liatopoulou S.;Bizzarri B.;Comparato G.;Cavestro G. M.;Di Mario F.
2007-01-01

Abstract

Background: Non-invasive methods are advisable for the detection of Helicobacter pylori-related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-H. pylori antibodies (IgG-Hp) have been proposed as a 'serological gastric biopsy'. Aim: To assess H. pylori infection and to evaluate gastric mucosa status in a pediatric population by means of serological parameters such as sPGI, sPGII, G-17 and IgG-Hp. Methods: 45 consecutively children evaluated for upper gastrointestinal symptoms were analyzed. All children were submitted to upper gastrointestinal endoscopy with biopsies. Serum samples were analyzed for IgG-Hp, sPGII, sPGI and G-17 (Biohit, Helsinki, Finland). Results: 18 children had H. pylori-related mild or moderate non-atrophic chronic gastritis. They presented significantly higher mean levels of sPGII and of IgG-Hp than negative ones, eitherunder or up to 10 years. sPGI showed significantly increased levels in H. pylori-positive patients only over 10 years. G-17 levels were not different between H. pylori-positive and -negative ones. The best cut-offs of IgG-Hp, sPGII and of product IgG-Hp·sPGII, to identify H. pylori infection, were 30 IU/l, 9 μg/l, and 241 IU/l·μg/l, respectively. The product IgG-Hp·sPGII identified H. pylori infection with a 100% sensitivity, 92% specificity, 90% positive predictive value and 100% negative predictive value. IgG-Hp and IgG-Hp showed a correlation (r = 0.94; p < 0.001). Conclusions: Combined analysis of sPGII and IgG-Hp antibody levels could be recommended as a non-invasive panel for the assessment of H. pylori-related histological alterations of gastric mucosa in childhood. Copyright © 2007 S. Karger AG.
2007
Usefulness of a serological panel test in the assessment of gastritis in symptomatic children / De Angelis, G. L.; Cavallaro, L. G.; Maffini, V.; Moussa, A. M.; Fornaroli, F.; Liatopoulou, S.; Bizzarri, B.; Merli, R.; Comparato, G.; Caruana, P.; Cavestro, G. M.; Franze, A.; Di Mario, F.. - In: DIGESTIVE DISEASES. - ISSN 0257-2753. - 25:3(2007), pp. 206-213. [10.1159/000103886]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2885320
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