Amino acid (AA) sequences of 807 bioactive peptides from foods of animal origin were examined in order to correlate peptide structure with activity (antihypertensive, antioxidative, immunomodulatory, antimicrobial, hypolipidemic, antithrombotic, and opioid) and stability in vivo. Food sources, such as milk, meat, eggs, and marine products, show different frequencies of bioactive peptides exhibiting specific effects. There is a correlation of peptide structure and effect, depending on type and position of AA. Opioid peptides contain a high percentage of aromatic AA residues, while antimicrobial peptides show an excess of positively charged AAs. AA residue position is significant, with those in the first and penultimate positions having the biggest effects on peptide activity. Peptides that have activity in vivo contain a high percentage (67%) of proline residues, but the positions of proline in the sequence depend on the length of the peptide. We also discuss the influence of processing on activity of these peptides, as well as methods for predicting release from the source protein and activity of peptides.

Meta-Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability / Maestri, Elena; Pavlicevic, Milica; Montorsi, Michela; Marmiroli, Nelson. - In: COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY. - ISSN 1541-4337. - 18:(2019), pp. 3-30. [10.1111/1541-4337.12402]

Meta-Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability

Elena Maestri
;
Nelson Marmiroli
2019-01-01

Abstract

Amino acid (AA) sequences of 807 bioactive peptides from foods of animal origin were examined in order to correlate peptide structure with activity (antihypertensive, antioxidative, immunomodulatory, antimicrobial, hypolipidemic, antithrombotic, and opioid) and stability in vivo. Food sources, such as milk, meat, eggs, and marine products, show different frequencies of bioactive peptides exhibiting specific effects. There is a correlation of peptide structure and effect, depending on type and position of AA. Opioid peptides contain a high percentage of aromatic AA residues, while antimicrobial peptides show an excess of positively charged AAs. AA residue position is significant, with those in the first and penultimate positions having the biggest effects on peptide activity. Peptides that have activity in vivo contain a high percentage (67%) of proline residues, but the positions of proline in the sequence depend on the length of the peptide. We also discuss the influence of processing on activity of these peptides, as well as methods for predicting release from the source protein and activity of peptides.
2019
Meta-Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability / Maestri, Elena; Pavlicevic, Milica; Montorsi, Michela; Marmiroli, Nelson. - In: COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY. - ISSN 1541-4337. - 18:(2019), pp. 3-30. [10.1111/1541-4337.12402]
File in questo prodotto:
File Dimensione Formato  
2019Maestripept10.1111_1541-4337.12402.pdf

solo utenti autorizzati

Descrizione: Articolo principale
Tipologia: Versione (PDF) editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 991.41 kB
Formato Adobe PDF
991.41 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
crf312402-corrected.pdf

Open Access dal 01/11/2019

Tipologia: Documento in Post-print
Licenza: Creative commons
Dimensione 1.93 MB
Formato Adobe PDF
1.93 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2850921
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 57
  • ???jsp.display-item.citation.isi??? 39
social impact