In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease / Checkoway, H; Franklin, G. M; Costa-Mallen, P; Smith-Weller, T; Dilley, J; Swanson, P. D; Costa, L. G.. - In: NEUROLOGY. - ISSN 0028-3878. - 50:5(1998), p. 1458-61.
A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease
Costa, L. G.
1998-01-01
Abstract
In a population-based case-control study, we found a reversal of the association of cigarette smoking with Parkinson's disease (PD) in relation to the monoamine oxidase B intron 13 genetic polymorphism. A reduced PD risk related to pack-years of smoking was detected for persons with the G allele, whereas an opposite effect was found among persons with the A allele. These results indicate an unexplained interaction between cigarette smoking and this genetic polymorphism.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
