Background: “Gluten-related disorders” is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively Aim: To support gastroenterologists with a correct nomenclature and diagnostic approach to glutenrelated disorders in adulthood. Methods: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of glutenrelated disorders, focusing on those of gastroenterological interest. Each member was assigned a task and levels of evidence/recommendation have been proposed. Results: The panel identified celiac disease, wheat allergy and non-celiac gluten sensitivity as the glutenrelated disorders of gastroenterological interest. Celiac disease has an autoimmune nature, wheat allergy is IgE-mediated while the pathogenesis of non-celiac gluten sensitivity is still unknown as is the case of non-IgE mediated allergy. Diagnosis should start with the serological screening for celiac disease and wheat allergy. In case of normal values, the response to a gluten-free diet should be evaluated and a confirmatory blind food challenge carried out. Conclusions: Gluten-related disorders are clinically heterogeneous. Patients should be carefully managed and specific protocols applied for a correct differential diagnosis in gastroenterological setting.

Nomenclature and diagnosis of gluten-related disorders: A position statement by the Italian Association of Hospital Gastroenterologists and endoscopists (AIGO) / Elli, L; Villalta, D; Roncoroni, L; Barisani, D; Ferrero, S; Pellegrini, Nicoletta; Bardella, Mt; Valiante, F; Tomba, C; Carroccio, A; Bellini, M; Soncini, M; Cannizzaro, R; Leandro, G.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 49:2(2017), pp. 138-146. [10.1016/j.dld.2016.10.016]

Nomenclature and diagnosis of gluten-related disorders: A position statement by the Italian Association of Hospital Gastroenterologists and endoscopists (AIGO).

PELLEGRINI, Nicoletta;
2017-01-01

Abstract

Background: “Gluten-related disorders” is a term that encompasses different diseases induced by the ingestion of gluten-containing food. Because of their incidence the scientific community has been intensively Aim: To support gastroenterologists with a correct nomenclature and diagnostic approach to glutenrelated disorders in adulthood. Methods: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) commissioned a panel of experts to prepare a position statement clarifying the nomenclature and diagnosis of glutenrelated disorders, focusing on those of gastroenterological interest. Each member was assigned a task and levels of evidence/recommendation have been proposed. Results: The panel identified celiac disease, wheat allergy and non-celiac gluten sensitivity as the glutenrelated disorders of gastroenterological interest. Celiac disease has an autoimmune nature, wheat allergy is IgE-mediated while the pathogenesis of non-celiac gluten sensitivity is still unknown as is the case of non-IgE mediated allergy. Diagnosis should start with the serological screening for celiac disease and wheat allergy. In case of normal values, the response to a gluten-free diet should be evaluated and a confirmatory blind food challenge carried out. Conclusions: Gluten-related disorders are clinically heterogeneous. Patients should be carefully managed and specific protocols applied for a correct differential diagnosis in gastroenterological setting.
2017
Nomenclature and diagnosis of gluten-related disorders: A position statement by the Italian Association of Hospital Gastroenterologists and endoscopists (AIGO) / Elli, L; Villalta, D; Roncoroni, L; Barisani, D; Ferrero, S; Pellegrini, Nicoletta; Bardella, Mt; Valiante, F; Tomba, C; Carroccio, A; Bellini, M; Soncini, M; Cannizzaro, R; Leandro, G.. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 49:2(2017), pp. 138-146. [10.1016/j.dld.2016.10.016]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2825211
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