Aflatoxins are a class of mycotoxins produced principally by Aspergillus flavus and Aspergillus parasiticus classified in Group 1 by IARC. Aflatoxins can occur naturally in food commodities as a result of fungal contamination in hot and humid environments. Aims of this project are the identification of new compounds that could inhibit Aspergillus proliferation and/or aflatoxin production and the set-up of a practical screening procedure to identify the most effective and safe compounds. We have recently evaluated the biological activity of two different molecules: perillaldehyde thiosemicarbazone and its nickel complex. These molecules once synthesized and characterized, were initially tested on fungal species belonging to the genus Aspergillus to determine their effects on fungal germination/growth and aflatoxin biosynthesis. These compounds showed different efficacy on fungal growth and on mycotoxin accumulation. The genotoxicity of these new compounds was assessed through Ames test and Alkaline Comet Assay on normal human cell lines to exclude potential danger to the environment and to human health. Financial support: Fondazione Cariplo-Project N. 2014-0555, http://aflatox.unibs.it/
A Biotechnological Approach for the Development of New Antifungal Compounds to Protect the Environment and the Human Health / Montalbano, Serena; Degola, Francesca; Galati, Serena; Pioli, Marianna; Spadola, G; Zani, C; Restivo, Francesco Maria; Carcelli, Mauro; Rogolino, Dominga; Feretti, D; Pelosi, Giorgio; Bisceglie, Franco; Buschini, Annamaria. - (2016). (Intervento presentato al convegno FISV XIV Congress tenutosi a Roma nel 20-23 settembre 2016).
A Biotechnological Approach for the Development of New Antifungal Compounds to Protect the Environment and the Human Health
MONTALBANO, SERENA;DEGOLA, Francesca;GALATI, Serena;PIOLI, MARIANNA;RESTIVO, Francesco Maria;CARCELLI, Mauro;ROGOLINO, Dominga;PELOSI, Giorgio;BISCEGLIE, Franco;BUSCHINI, Annamaria
2016-01-01
Abstract
Aflatoxins are a class of mycotoxins produced principally by Aspergillus flavus and Aspergillus parasiticus classified in Group 1 by IARC. Aflatoxins can occur naturally in food commodities as a result of fungal contamination in hot and humid environments. Aims of this project are the identification of new compounds that could inhibit Aspergillus proliferation and/or aflatoxin production and the set-up of a practical screening procedure to identify the most effective and safe compounds. We have recently evaluated the biological activity of two different molecules: perillaldehyde thiosemicarbazone and its nickel complex. These molecules once synthesized and characterized, were initially tested on fungal species belonging to the genus Aspergillus to determine their effects on fungal germination/growth and aflatoxin biosynthesis. These compounds showed different efficacy on fungal growth and on mycotoxin accumulation. The genotoxicity of these new compounds was assessed through Ames test and Alkaline Comet Assay on normal human cell lines to exclude potential danger to the environment and to human health. Financial support: Fondazione Cariplo-Project N. 2014-0555, http://aflatox.unibs.it/I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
