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CORRELATION OF A QUANTITATIVE VIDEOCAPILLAROSCOPIC SCORE WITH THE DEVELOPMENT OF DIGITAL SKIN ULCERS IN SCLERODERMA PATIENTS

Background: Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and visceral organs. SSc microangiopathy is early detectable in the course of the disease by nailfold videocapillaroscopy (NVC), a non-invasive technique with a high diagnostic value.Objectives: Aim of our study is to evaluate the feasibility of a novel, quantitative capillaroscopic score and its correlation with digital skin ulcers, which frequently complicate SSc microangiopathy.Methods: Two ...

The Expanding Spectrum of Clinical Features in HCV-Related Mixed Cryoglobulinemia

Mixed cryoglobulinemia (MC) is a relatively rare disorder that may complicate numerous infectiousor immuno/hematological diseases. Classical MC syndrome is associated with hepatitis C virus (HCV)infection in the large majority of patients and the virus is suspected in the etiopathogenesis of the disease.MC syndrome, or cryoglobulinemic vasculitis, is characterized by a clinical triad of purpura, weakness,and arthralgias and by variable organ and, in many cases, endocrine involvement. As a lat...

Cardiac Involvement in Systemic Vasculitis

Systemic vasculitides are a heterogeneous group of diseases characterized by inflammation of vessels, which can result in their obstruction and/or aneurysm formation. The evidence of the inflammation of blood vessel walls in at least one occasion during the course is a shared defining feature of all categories of vasculitis. Their classification varies according to etiology, pathogenesis, type of vessel affected, type of inflammation, and favored organ distribution. Almost all primary vasculitides...

Chapter 52 - Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection

The term cryoglobulinemia refers to the presence in the serum of one (monoclonal cryoimmunoglobulinemia) or more immunoglobulins (mixed cryoglobulinemia, MC), which precipitate at temperatures below 37 °C and redissolve on rewarming; this is an in vitro phenomenon that can be associated to a large number of benign or malignant disorders. In addition, type II mixed cryoglobulins are often composed by oligoclonal IgM or a mixture of polyclonal and monoclonal IgM. This type II–III MC could repre...

Cryoglobulinaemia and hepatitis C virus

description of mixed cryoglobulinemia, pathophisiology, clinica features, prognosis, therapy guidelines.

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