The aim of this paper is to present a novel inversion technique to measure the volume of thrombus induced under blood flow conditions in a lab-on-a-chip device. The device is composed by a microscope slide where parallel gold electrodes are sputtered and by a PDMS microchannel placed on the top of the slide. A thrombogenic substance is placed on the slide in such a way that hemostasis is induced when whole blood flows in the microchannel. The novel idea behind the inversion technique is to fuse optical and electrical impedance data to obtain a quasi real-time reconstruction of thrombus volume. This is not possible with the present state of the art optical imaging based on confocal microscopy that provides the thrombus volume estimation only at the end of the thrombus formation.
A Novel Inversion Technique for Imaging Thrombus Volume in Microchannels Fusing Optical and Impedance Data / Antonio, Affanni; Chiorboli, Giovanni; Lorenzo, Codecasa; Maria Rita, Cozzi; Luigi De, Marco; Mario, Mazzucato; Carlo, Morandi; Ruben, Specogna; Marco, Tartagni; Francesco, Trevisan. - (2013). (Intervento presentato al convegno 19th International Conference on the Computation of Electromagnetic Fields tenutosi a Budapest nel 30 June - 4 July 2013).
A Novel Inversion Technique for Imaging Thrombus Volume in Microchannels Fusing Optical and Impedance Data
CHIORBOLI, Giovanni;
2013-01-01
Abstract
The aim of this paper is to present a novel inversion technique to measure the volume of thrombus induced under blood flow conditions in a lab-on-a-chip device. The device is composed by a microscope slide where parallel gold electrodes are sputtered and by a PDMS microchannel placed on the top of the slide. A thrombogenic substance is placed on the slide in such a way that hemostasis is induced when whole blood flows in the microchannel. The novel idea behind the inversion technique is to fuse optical and electrical impedance data to obtain a quasi real-time reconstruction of thrombus volume. This is not possible with the present state of the art optical imaging based on confocal microscopy that provides the thrombus volume estimation only at the end of the thrombus formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
