1. The gastroprotective activity of two azomethine prodrugs of (R)-alpha-methylhistamine was examined in lesions induced by absolute ethanol (1 ml/rat intragastrically for 1 h). 2. Pretreatment with (R)-alpha-methylhistamine as well as with the prodrugs (30 and 100 mg/kg intragastrically [IG]) significantly reduced macroscopically visible lesions caused by ethanol, with protection being almost complete at 100 mg/kg. 3. Histologically, in rats pretreated with the three compounds ata dose of 100 mg/kg, the evidence of ; damage was rare, with the appearance of gastric mucosa being similar in the different treatment groups. 4. Present results are suggestive of a local component in the protective activity of (R)-alpha-methylhistamine
Comparison of the protective effect of (R)-alpha-methylhistamine and its prodrugs on gastric mucosal damage induced by ethanol in the rat / Morini, Giuseppina; Grandi, Daniela; G., Bertaccini. - In: GENERAL PHARMACOLOGY. - ISSN 0306-3623. - 27:8(1996), pp. 1391-1394. [10.1016/S0306-3623(96)00068-7]
Comparison of the protective effect of (R)-alpha-methylhistamine and its prodrugs on gastric mucosal damage induced by ethanol in the rat
MORINI, Giuseppina;GRANDI, Daniela;
1996-01-01
Abstract
1. The gastroprotective activity of two azomethine prodrugs of (R)-alpha-methylhistamine was examined in lesions induced by absolute ethanol (1 ml/rat intragastrically for 1 h). 2. Pretreatment with (R)-alpha-methylhistamine as well as with the prodrugs (30 and 100 mg/kg intragastrically [IG]) significantly reduced macroscopically visible lesions caused by ethanol, with protection being almost complete at 100 mg/kg. 3. Histologically, in rats pretreated with the three compounds ata dose of 100 mg/kg, the evidence of ; damage was rare, with the appearance of gastric mucosa being similar in the different treatment groups. 4. Present results are suggestive of a local component in the protective activity of (R)-alpha-methylhistamineI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
