Until a decade ago, hematopoietic stem cell transplantation from related donor mismatched at two or three HLA-A, -B or DR loci was largely unsuccessful in leukemia patients because of severe graft-versus-host disease in unmanipulated bone marrow transplants and graft failure in extensively T-cell-depleted transplants. The breakthrough came with the use of a megadose of T-cell-depleted hematopoietic progenitor cells. Donor-vs-recipient natural killer cell alloreactivity also plays a role in facilitating engraftment and in preventing relapse of acute myeloid leukemia. Event-free survival and transplant-related mortality for high risk acute leukemia patients treated at less advanced stages of disease compare favourably with reports from unrelated matched transplants.

Hematopoietic stem cell transplantation from full-haplotype mismatched donors / Aversa, Franco. - In: TRANSFUSION AND APHERESIS SCIENCE. - ISSN 1473-0502. - 27:(2002), pp. 175-181.

Hematopoietic stem cell transplantation from full-haplotype mismatched donors.

AVERSA, Franco
2002-01-01

Abstract

Until a decade ago, hematopoietic stem cell transplantation from related donor mismatched at two or three HLA-A, -B or DR loci was largely unsuccessful in leukemia patients because of severe graft-versus-host disease in unmanipulated bone marrow transplants and graft failure in extensively T-cell-depleted transplants. The breakthrough came with the use of a megadose of T-cell-depleted hematopoietic progenitor cells. Donor-vs-recipient natural killer cell alloreactivity also plays a role in facilitating engraftment and in preventing relapse of acute myeloid leukemia. Event-free survival and transplant-related mortality for high risk acute leukemia patients treated at less advanced stages of disease compare favourably with reports from unrelated matched transplants.
2002
Hematopoietic stem cell transplantation from full-haplotype mismatched donors / Aversa, Franco. - In: TRANSFUSION AND APHERESIS SCIENCE. - ISSN 1473-0502. - 27:(2002), pp. 175-181.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2438976
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