Abstract Experiments carried out in vivo with WSN (H0N1) and FPV (Hav1N1) strains of influenza virus have shown the presence of phosphorylated virus-induced polypeptides. Notably it was interesting the behaviour of the non-structural NS1, NP nucleoprotein and membrane M viral components whose phosphorylation was different among the cellular hosts tested. In in vitro experiments we were able to demonstrate a protein-kinase-activity in purified virions. The similarities and differences found in vivo and in vitro systems are discussed taking into consideration the fact that viral replicative cycle is closely dependent from the cellular host and the pattern of influenza virus infection is unique between different hosts. PMID: 7236359 [PubMed - indexed for MEDLINE]
Phosphorylation of viral polypeptides in cells infected with influenza virus / Conti, Giorgio; Natali, A; Valcavi, P; Schito, Gc. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 59(6):(1980), pp. 581-590.
Phosphorylation of viral polypeptides in cells infected with influenza virus
CONTI, Giorgio;
1980-01-01
Abstract
Abstract Experiments carried out in vivo with WSN (H0N1) and FPV (Hav1N1) strains of influenza virus have shown the presence of phosphorylated virus-induced polypeptides. Notably it was interesting the behaviour of the non-structural NS1, NP nucleoprotein and membrane M viral components whose phosphorylation was different among the cellular hosts tested. In in vitro experiments we were able to demonstrate a protein-kinase-activity in purified virions. The similarities and differences found in vivo and in vitro systems are discussed taking into consideration the fact that viral replicative cycle is closely dependent from the cellular host and the pattern of influenza virus infection is unique between different hosts. PMID: 7236359 [PubMed - indexed for MEDLINE]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
