Acute myeloid leukaemia (AML) with mutated nucleophosmin (NPM1), accounting for about 30% of adult de novo AML1 and 7% of childhood AML,2 displays distinctive biological and clinical characteristics.3 We report for the first time on the clinical, pathological and molecular features of NPM1-mutated AML which developed almost simultaneously (at an interval of only 2 months) in a father and his daughter, and discuss the biological significance of this finding.
Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family / G., Cazzaniga; L., Lo Nigro; I., Cifola; G., Milone; S., Schnittger; T., Haferlach; E., Mirabile; F., Costantino; Martelli, M. P.; E., Mastrodicasa; F., Di Raimondo; Aversa, Franco; A., Biondi; B., Falini. - In: LEUKEMIA. - ISSN 0887-6924. - 23:(2009), pp. 199-203. [10.1038/leu.2008.170]
Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family.
AVERSA, Franco;
2009-01-01
Abstract
Acute myeloid leukaemia (AML) with mutated nucleophosmin (NPM1), accounting for about 30% of adult de novo AML1 and 7% of childhood AML,2 displays distinctive biological and clinical characteristics.3 We report for the first time on the clinical, pathological and molecular features of NPM1-mutated AML which developed almost simultaneously (at an interval of only 2 months) in a father and his daughter, and discuss the biological significance of this finding.| File | Dimensione | Formato | |
|---|---|---|---|
|
Leukemia 2009.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
445.31 kB
Formato
Adobe PDF
|
445.31 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
