BACKGROUND: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC).METHODS: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene.RESULTS: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p < 0.001).CONCLUSION: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.

Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer? / Bozzetti, C.; Tiseo, M.; Lagrasta, Costanza Anna Maria; Nizzoli, R.; Guazzi, A.; Graiani, G.; Rindi, G.; Ardizzoni, A.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 5:(2010), pp. 551-553. [10.1097/JTO.0b013e3181ce3b28]

Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer?

M. Tiseo;LAGRASTA, Costanza Anna Maria;
2010-01-01

Abstract

BACKGROUND: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC).METHODS: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene.RESULTS: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p < 0.001).CONCLUSION: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.
2010
Is cytology reliable for epidermal growth factor receptor gene evaluation in non-small cell lung cancer? / Bozzetti, C.; Tiseo, M.; Lagrasta, Costanza Anna Maria; Nizzoli, R.; Guazzi, A.; Graiani, G.; Rindi, G.; Ardizzoni, A.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 5:(2010), pp. 551-553. [10.1097/JTO.0b013e3181ce3b28]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2391531
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