ABSTRACT: BACKGROUND: Rituximab is a monoclonal antibody inducing depletion of B lymphocytes and presently approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis. Here is the first report of the use of this drug in a case of Cogan's syndrome (CS). Case Presentation: a 25-year-old Italian woman was referred with conjunctival hyperaemia, interstitial keratitis, moderate bilateral sensorineural hearing loss accompanied by tinnitus, dizziness, nausea and vertigo, poorly responsive to oral and topical steroidal therapy. Diagnosis of typical CS was made. The administration of a combined immunosuppressive treatment resolved ocular inflammation, dizziness, nausea, and vertigo but gave little results in controlling progressive hearing loss. A noticeable improvement in hearing function was documented by pure tone audiometry after infusion of Rituximab. DISCUSSION: in CS, hearing function is often the most difficult parameter to control with therapy. A positive effect of Rituximab on was observed in our case. The drug also allowed to significantly reduce the number of adjuvant immunosuppressive medications.

Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report / Orsoni, Gabriella; Lagana, B; Rubino, P; Zavota, L; Bacciu, Salvatore; Mora, Paolo. - In: ORPHANET JOURNAL OF RARE DISEASES. - ISSN 1750-1172. - 5:(2010), pp. 18-18. [10.1186/1750-1172-5-18]

Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report.

ORSONI, Gabriella;BACCIU, Salvatore;MORA, Paolo
2010-01-01

Abstract

ABSTRACT: BACKGROUND: Rituximab is a monoclonal antibody inducing depletion of B lymphocytes and presently approved for the treatment of non-Hodgkin's lymphoma and rheumatoid arthritis. Here is the first report of the use of this drug in a case of Cogan's syndrome (CS). Case Presentation: a 25-year-old Italian woman was referred with conjunctival hyperaemia, interstitial keratitis, moderate bilateral sensorineural hearing loss accompanied by tinnitus, dizziness, nausea and vertigo, poorly responsive to oral and topical steroidal therapy. Diagnosis of typical CS was made. The administration of a combined immunosuppressive treatment resolved ocular inflammation, dizziness, nausea, and vertigo but gave little results in controlling progressive hearing loss. A noticeable improvement in hearing function was documented by pure tone audiometry after infusion of Rituximab. DISCUSSION: in CS, hearing function is often the most difficult parameter to control with therapy. A positive effect of Rituximab on was observed in our case. The drug also allowed to significantly reduce the number of adjuvant immunosuppressive medications.
2010
Rituximab ameliorated severe hearing loss in Cogan's syndrome: a case report / Orsoni, Gabriella; Lagana, B; Rubino, P; Zavota, L; Bacciu, Salvatore; Mora, Paolo. - In: ORPHANET JOURNAL OF RARE DISEASES. - ISSN 1750-1172. - 5:(2010), pp. 18-18. [10.1186/1750-1172-5-18]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2312224
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