Copper complexes of thiosemicarbazones of imidazole-2-carbaldehyde, pyrrole-2-carbaldehyde and indole-3-carbaldehyde were synthesised and characterised. The antimicrobial properties of the free ligands and their complexes were evaluated against yeasts, moulds and bacteria (Gram-positive and Gram-negative). Some copper chelates exhibited a moderate inhibitory activity, better than that of the corresponding free ligands. In particular, the pyrrole derivative [Cu(HL2)2] proved to be a wide spectrum agent, showing an interesting inhibition of the growth of all Gram-positive bacteria and fungi tested at concentrations of 12–50 microg/mL. In contrast, a selective effect was observed for imidazole and indole chelates against fungi and Gram-positive bacteria, respectively.

Copper complexes of imidazole-2-, pyrrole-2-and indol-3-carbaldehyde thiosemicarbazones: Inhibitory activity against fungi and bacteria / RODRIGUEZ ARGUELLES, M. C.; LOPEZ SILVA, E. C.; Sanmartin, J.; Pelagatti, Paolo; Zani, Franca. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 99:(2005), pp. 2231-2239. [10.1016/j.jinorgbio.2005.07.018]

Copper complexes of imidazole-2-, pyrrole-2-and indol-3-carbaldehyde thiosemicarbazones: Inhibitory activity against fungi and bacteria

PELAGATTI, Paolo;ZANI, Franca
2005-01-01

Abstract

Copper complexes of thiosemicarbazones of imidazole-2-carbaldehyde, pyrrole-2-carbaldehyde and indole-3-carbaldehyde were synthesised and characterised. The antimicrobial properties of the free ligands and their complexes were evaluated against yeasts, moulds and bacteria (Gram-positive and Gram-negative). Some copper chelates exhibited a moderate inhibitory activity, better than that of the corresponding free ligands. In particular, the pyrrole derivative [Cu(HL2)2] proved to be a wide spectrum agent, showing an interesting inhibition of the growth of all Gram-positive bacteria and fungi tested at concentrations of 12–50 microg/mL. In contrast, a selective effect was observed for imidazole and indole chelates against fungi and Gram-positive bacteria, respectively.
2005
Copper complexes of imidazole-2-, pyrrole-2-and indol-3-carbaldehyde thiosemicarbazones: Inhibitory activity against fungi and bacteria / RODRIGUEZ ARGUELLES, M. C.; LOPEZ SILVA, E. C.; Sanmartin, J.; Pelagatti, Paolo; Zani, Franca. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 99:(2005), pp. 2231-2239. [10.1016/j.jinorgbio.2005.07.018]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1446143
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