In this paper the syntheses of new pyridoxal thiosemicarbazone copper(II) and cobalt(III) complexes with nitroprusside as a counterion and tests on the antileukemic activity of three of these complexes toward human cell lines U937 and CEM are reported. Nitroprusside was chosen in order to test if its ability to release NO can increase the biological activity already shown by these complexes. The compounds were characterized by spectroscopic and magnetic methods and by single-crystal X-ray diffraction.

Copper(II) and Cobalt(III) Pyridoxal Thiosemicarbazone Complexes with Nitroprusside as Counterion: Syntheses, Electronic Properties, and Antileukemic Activity / Ferrari, Marisa; Bisceglie, Franco; Casoli, Claudio; Durot, S.; MORGENSTERN BADARAU, I.; Pelosi, Giorgio; Pilotti, Elisabetta; Pinelli, Silvana; Tarasconi, Pieralberto. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:(2005), pp. 1671-1675. [10.1021/jm049529n]

Copper(II) and Cobalt(III) Pyridoxal Thiosemicarbazone Complexes with Nitroprusside as Counterion: Syntheses, Electronic Properties, and Antileukemic Activity

FERRARI, Marisa;BISCEGLIE, Franco;CASOLI, Claudio;PELOSI, Giorgio;PILOTTI, Elisabetta;PINELLI, Silvana;TARASCONI, Pieralberto
2005-01-01

Abstract

In this paper the syntheses of new pyridoxal thiosemicarbazone copper(II) and cobalt(III) complexes with nitroprusside as a counterion and tests on the antileukemic activity of three of these complexes toward human cell lines U937 and CEM are reported. Nitroprusside was chosen in order to test if its ability to release NO can increase the biological activity already shown by these complexes. The compounds were characterized by spectroscopic and magnetic methods and by single-crystal X-ray diffraction.
2005
Copper(II) and Cobalt(III) Pyridoxal Thiosemicarbazone Complexes with Nitroprusside as Counterion: Syntheses, Electronic Properties, and Antileukemic Activity / Ferrari, Marisa; Bisceglie, Franco; Casoli, Claudio; Durot, S.; MORGENSTERN BADARAU, I.; Pelosi, Giorgio; Pilotti, Elisabetta; Pinelli, Silvana; Tarasconi, Pieralberto. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - 48:(2005), pp. 1671-1675. [10.1021/jm049529n]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1444075
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