Proceedings of the 23rd Meeting of the European Society of Veterinary Pathology EVALUATION OF DIFFERENT PLASMID DNA DELIVERY SYSTEMS FOR ANTI-HER2/NEU IMMUNIZATION IN A TRANSGENIC MURINE MODEL OF MAMMARY CARCINOMA. 23rd Meeting of the European Society of Veterinary Pathology 55 A. Smorlesi1, F.Papalini1, A. Amici1, F. Orlando1, S. Pierpaoli1, C. Mancini1, P. Borghetti2, A. Corradi2, M Provinciali1 1Laboratory of Tumor Immunology, Immunology Center, INRCA Res. Dept., Italy; 2Pathology Unit, Dpt. Animal Health, Via del Taglio 8, 43100-Parma, Italy, attilio.corradi@unipr.it Studies of anti-HER2/neu DNA vaccination showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumours; scarce information, however, has been provided to identify the procedure of DNA administration more effective in activating immune system against spontaneously arising HER2/neu-positive tumours. We compared the effectiveness of different procedures of DNA vaccine delivery (intradermic injection, Gene Gun delivery and intramuscolar injection alone or with electroporation) in a transgenic model of mammary carcinoma HER2/neuoverexpressing. We highlighted the role of DNA delivery system in the success of DNA vaccination showing that, among the analysed methods, intramuscolar injection of the vaccine, particularly when associated to electroporation, elicits a better protection against HER2/neu spontaneous tumour and induces a Th1-like immunity.

Evaluation of different plasmid DNA delivery systems for anti-HER2/neu immunization in a transgenic murine model of mammary carcinoma / Smorlesi, A.; Papalini, F.; Amici, A.; Orlando, F.; Pierpaoli, S.; Mancini, C.; Borghetti, Paolo; Corradi, Attilio; Provinciali, M.. - Proceedings:1(2005), pp. 55-55. (Intervento presentato al convegno 23rd Meeting of the European Society of Veterinary Pathology nel 7/10 settembre 2005).

Evaluation of different plasmid DNA delivery systems for anti-HER2/neu immunization in a transgenic murine model of mammary carcinoma

BORGHETTI, Paolo;CORRADI, Attilio;
2005-01-01

Abstract

Proceedings of the 23rd Meeting of the European Society of Veterinary Pathology EVALUATION OF DIFFERENT PLASMID DNA DELIVERY SYSTEMS FOR ANTI-HER2/NEU IMMUNIZATION IN A TRANSGENIC MURINE MODEL OF MAMMARY CARCINOMA. 23rd Meeting of the European Society of Veterinary Pathology 55 A. Smorlesi1, F.Papalini1, A. Amici1, F. Orlando1, S. Pierpaoli1, C. Mancini1, P. Borghetti2, A. Corradi2, M Provinciali1 1Laboratory of Tumor Immunology, Immunology Center, INRCA Res. Dept., Italy; 2Pathology Unit, Dpt. Animal Health, Via del Taglio 8, 43100-Parma, Italy, attilio.corradi@unipr.it Studies of anti-HER2/neu DNA vaccination showed the effectiveness of immunization protocols in models of transplantable or spontaneous tumours; scarce information, however, has been provided to identify the procedure of DNA administration more effective in activating immune system against spontaneously arising HER2/neu-positive tumours. We compared the effectiveness of different procedures of DNA vaccine delivery (intradermic injection, Gene Gun delivery and intramuscolar injection alone or with electroporation) in a transgenic model of mammary carcinoma HER2/neuoverexpressing. We highlighted the role of DNA delivery system in the success of DNA vaccination showing that, among the analysed methods, intramuscolar injection of the vaccine, particularly when associated to electroporation, elicits a better protection against HER2/neu spontaneous tumour and induces a Th1-like immunity.
2005
Evaluation of different plasmid DNA delivery systems for anti-HER2/neu immunization in a transgenic murine model of mammary carcinoma / Smorlesi, A.; Papalini, F.; Amici, A.; Orlando, F.; Pierpaoli, S.; Mancini, C.; Borghetti, Paolo; Corradi, Attilio; Provinciali, M.. - Proceedings:1(2005), pp. 55-55. (Intervento presentato al convegno 23rd Meeting of the European Society of Veterinary Pathology nel 7/10 settembre 2005).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/1443948
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