Sfoglia per Autore
Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase.
2003-01-01 Pellicciari, R; Amori, L; Costantino, Gabriele; Giordani, A; Macchiarulo, A; Mattoli, L; Pevarello, P; Speciale, C; Varasi, M.
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.
2003-01-01 Chiarugi, A; Meli, E; Calvani, M; Picca, R; Baronti, R; Camaioni, E; Marinozzi, M; Pellegrinigiampietro, De; Pellicciari, R; Costantino, Gabriele
The role of electrostatic interaction in the molecular recognition of selective agonists to metabotropic glutamate receptors
2003-01-01 Macchiarulo, A; Sbaglia, R; Aiello, S; Meniconi, M; Costantino, Gabriele
Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors
2003-01-01 Pellicciari, R; Camaioni, E; Marinozzi, M; Macchiarulo, A; Moroni, F; Costantino, Gabriele
Binding mode of 6ECDCA, a potent bile acid agonist of the farnesoid X receptor (FXR)
2003-01-01 Costantino, Gabriele; Macchiarulo, A; ENTRENA GUADIX, A; Camaioni, E; Pellicciari, R.
Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.
2004-01-01 Pellicciari, R; Camaioni, E; Costantino, Gabriele
Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid.
2004-01-01 Pellicciari, R; Costantino, Gabriele; Camaioni, E; Sadeghpour, Bm; Entrena, A; Willson, Tm; Fiorucci, S; Clerici, C; Gioiello, A.
Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses
2004-01-01 Macchiarulo, A; Costantino, Gabriele; Meniconi, M; Pleban, K; Ecker, G; Bellocchi, D; Pellicciari, R.
Homology model of the multidrug transporter LmrA from Lactococcus lactis.
2004-01-01 Pleban, K; Macchiarulo, A; Costantino, Gabriele; Pellicciari, R; Chiba, P; Ecker, Gf
QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor.
2004-01-01 Macchiarulo, A; DE LUCA, L; Costantino, Gabriele; Barreca, Ml; Gitto, R; Pellicciari, R; Chimirri, A.
Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist.
2004-01-01 Costantino, Gabriele; Marinozzi, M; Camaioni, E; Natalini, B; Sarichelou, I; Micheli, F; Cavanni, P; Faedo, S; Noe, C; Moroni, F; Pellicciari, R.
Design, synthesis, and microbiological evaluation of new Candida albicans CYP51 inhibitors.
2005-01-01 Schiaffella, F; Macchiarulo, A; Milanese, L; Vecchiarelli, A; Costantino, Gabriele; Pietrella, D; Fringuelli, R.
Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.
2005-01-01 Meyer, U; Costantino, Gabriele; Macchiarulo, A; Pellicciari, R.
Farnesoid X receptor: from structure to potential clinical applications.
2005-01-01 Pellicciari, R; Costantino, Gabriele; Fiorucci, S.
Molecular dynamics simulation of the ligand binding domain of farnesoid X receptor. Insights into helix-12 stability and coactivator peptide stabilization in response to agonist binding.
2005-01-01 Costantino, Gabriele; ENTRENA GUADIX, A; Macchiarulo, A; Gioiello, A; Pellicciari, R.
Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecule.
2005-01-01 Bellocchi, D; Macchiarulo, A; Costantino, Gabriele; Pellicciari, R.
Synthesis and biological evaluation of (2S)- and (2R)-2-(3'-phosphonobicyclo[1.1.1]pentyl)glycines as novel group III selective metabotropic glutamate receptor ligands.
2006-01-01 Filosa, R.; Marinozzi, M.; Costantino, Gabriele; Hermit, M. B.; Thomsen, C.; Pellicciari, R.
In silico approaches towards the understanding of the structure-function relationships in metabotropic glutamate receptors (mGluRs) and other family C GPRCs.
2006-01-01 Costantino, Gabriele
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators
2006-01-01 R., Pellicciari; A., Gioiello; Costantino, Gabriele
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives.
2006-01-01 Pellicciari, R.; Gioiello, A.; Sadeghpour, B. M.; Rizzo, G.; Meyer, U.; Parks, D. J.; ENTRENA GUADIX, A.; Costantino, Gabriele
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